糖尿病合并脑梗死患者外周血T淋巴细胞亚群与基质金属蛋白酶9的相关性

被引：19

作者：

张津华

马丽丽

李江坤

苏建

付志新

机构：

[1] 开封市中心医院神经内科

来源：

中华老年心脑血管病杂志 | 2015年 / 17卷 / 01期

关键词：

T淋巴细胞亚群; 基质金属蛋白酶9; 糖尿病; 脑梗死;

D O I：

暂无

中图分类号：

R587.1 [糖尿病]; R743.3 [急性脑血管疾病（中风）];

学科分类号：

100201 [内科学]; 100204 [神经病学];

摘要：

目的观察糖尿病合并脑梗死患者外周血T淋巴细胞亚群和基质金属蛋白酶9(matrix metalloproteinases 9,MMP-9)的相关性。方法选择住院治疗的急性脑梗死患者164例,将37例合并糖尿病的脑梗死患者作为合并组,127例无糖尿病的脑梗死患者作为脑梗死组。在发病48h内进行MMP-9、CD4T淋巴细胞、CD8T淋巴细胞和CD4/CD8比值检测,并进行相关性分析。结果与脑梗死组比较,合并组MMP-9水平升高[(8.78±2.85)μg/L vs(5.14±2.13)μg/L,P=0.046],CD8T淋巴细胞升高[(47.00±15.42)%vs(37.25±17.90)%,P=0.005],CD4T淋巴细胞降低[(14.80±6.39)%vs(20.98±12.74)%,P=0.029],CD4/CD8比值降低[(0.33±0.16)vs(0.51±0.25),P=0.015]。合并组和脑梗死组MMP-9与CD8T淋巴细胞呈正相关(r=0.774,P=0.041;r=0.526,P=0.037),与CD4T淋巴细胞呈负相关(r=-0.810,P=0.043;r=-0.633,P=0.036),与CD4/CD8比值呈负相关(r=-0.701,P=0.028;r=-0.616,P=0.045)。结论糖尿病合并脑梗死患者较非糖尿病的脑梗死患者更容易出现T淋巴细胞亚群紊乱,与MMP-9表达异常密切相关。

引用

页码：67 / 69

页数：3

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