国产奥沙利铂联合亚叶酸钙和氟尿嘧啶治疗晚期胃癌的临床研究

被引：9

作者：

谭立新

杨玲

李沛霖

李扬

机构：

[1] 首都医科大学附属复兴医院消化肿瘤科

[2] 首都医科大学附属复兴医院消化肿瘤科北京

[3] 北京

来源：

临床肿瘤学杂志 | 2005年 / 02期

关键词：

晚期胃癌; 联合化疗; 奥沙利铂; 亚叶酸钙; 氟尿嘧啶;

D O I：

暂无

中图分类号：

R735.2 [胃肿瘤];

学科分类号：

100214 ;

摘要：

目的:评价奥沙利铂(OXA)联合亚叶酸钙(LV)和氟尿嘧啶(5-Fu)方案治疗国人晚期胃癌的近期疗效和毒性反应。方法: 28例晚期胃癌,给予FOLFOX改良方案,即OXA120mg/m、静脉滴注4小时,LV200mg、静脉滴注2小时, 5-Fu500mg于LV滴完后静脉推注, 5-Fu3.0g持续静脉滴注46小时,每3周重复。按WHO标准评价近期疗效和毒性反应;同时观察TTP和MST。结果:可评价疗效者26例,获得PR11例(42.31% ),SD11例(42.31% ),PD4例(15.38% ),总有效率(CR+PR)为42.31%。中位TTP5 6个月,MST9个月。主要毒性反应为恶心、呕吐、骨髓抑制及一过性感觉异常,全组无治疗相关性死亡。结论:OXA联合LV/5-Fu组成的FOLFOX改良方案治疗晚期胃癌患者有效,临床缓解率较高,不良反应轻,可以耐受。

引用

页码：169 / 171

页数：3

共 6 条

[1]

A randomised phase II study of oxaliplatin alone versus oxaliplatin combined with 5 -fluorouracil and folinic acid ( Mayo Clinic regimen) in previously untreated metastatic colorectal cancer patients. Zori Comba A,Blajman C,Richardet E,et al. European Journal of Cancer . 2001

[2]

Adjuvant therapy for colon cancer in the new millenium. Rao S,Cunningham D. Scand J Surg . 2003

[3]

High-dose folinic acid and 5 -fluorouracil bolus and continuous infusion in advanced colorectal cancer. De Gramont A,Krulik M,Cady J,et al. European Journal of Cancer and Clinical Oncology . 1988

[4]

The treatment of advanced colorectal cancer: where are we now and where do we go?. Van Cutsem E,Verslype C,Demedts I. Bailliere s Best Practice and Research Clinical Gastroenterology . 2002

[5]

Phase II trial of biweekly infusional fluorouracil, folinic acid, and oxaliplatin in patients with advanced gastric cancer. Al-Batran SE,Atmaca A,Hegewisch-Becker S,et al. Journal of Clinical Oncology . 2004

[6]

Phase II study of oxaliplatin, 5 fluorouracil and leucovorin in previously platinum-treated patients with advanced gastric cancer. Kim DY,Kim JH,Lee SH,et al. Annals of Oncology . 2003

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