DNA氧化性损伤与端粒缩短

被引:12
作者
赵晨阳
郑荣梁
机构
[1] 兰州大学生物系!兰州
关键词
活性氧; DNA损伤; 端粒; 衰老; 癌变;
D O I
暂无
中图分类号
Q754 [基因的结构和突变的分子原理];
学科分类号
摘要
末端复制问题 (theendreplicationproblem)不能完全解释端粒在某些细胞分裂过程中迅速缩短的现象 .40 %的高压氧下细胞传代次数降低 ,端粒缩短速率增大 ,细胞出现衰老特征 ,端粒DNA上单链断裂积累 .推测端粒缩短的主要原因在于衰老过程中或氧胁迫下端粒DNA单链断裂增多 ,使端粒末端单链片段在DNA复制时丢失 .端粒酶和活性氧对端粒长度的正负调控作用的准确机制还有待于更深入的研究 .
引用
收藏
页码:351 / 353
页数:3
相关论文
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