普罗布考对颈动脉粥样硬化斑块稳定性影响的临床研究

被引：16

作者：

贾伟华 ^{[1
]}

周立春 ^{[1
]}

田桂玲 ^{[2
]}

机构：

[1] 首都医科大学附属北京朝阳医院神经内科(京西院区)

[2] 天津医科大学总医院神经内科

来源：

中国新药杂志 | 2007年 / 03期

关键词：

普罗布考; 斑块; 颈动脉; 稳定性; 声学光密度;

D O I：

暂无

中图分类号：

R743 [脑血管疾病];

学科分类号：

摘要：

目的:研究普罗布考对颈动脉粥样硬化斑块的治疗作用。方法:75例确诊颈动脉粥样硬化斑块的患者双盲随机分成试验组(n=38)和对照组(n=37),对照组行常规治疗,试验组在常规治疗的基础上,加服普罗布考(po,250 mg,bid,给药4个月)观察用药前后患者血脂[总胆固醇(TC),三酰甘油(TG),低密度脂蛋白胆固醇(LDL-C),高密度脂蛋白胆固醇(HDL-C)]变化及斑块声学密度的变化。结果:治疗后4个月,试验组血清TC,TG,LDL-C较治疗前明显降低(P<0.05),也显著低于对照组(P<0.05);HDL-C值较治疗前显著增加(P<0.05),也显著高于对照组(P<0.05)。试验组低回声斑块声学密度的背向散射积分值(IBS)较治疗前显著升高(P<0.05),也显著高于对照组(P<0.05)。结论:普罗布考可以降低血脂,改善低回声斑块组织学构成,增加斑块密度,从而稳定斑块。

引用

页码：237 / 239

页数：3

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