氯吡格雷与质子泵抑制剂的相互作用

被引：10

作者：

杨帆

谭保平

赖沙毅

机构：

[1] 广西医科大学第四附属医院心内科

来源：

中国新药与临床杂志 | 2009年 / 28卷 / 10期

关键词：

氯吡格雷; 抗凝药; 抗溃疡病药; 药物相互作用; 质子泵抑制剂; 心血管事件;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

抗血小板药物可有效降低血栓事件的发生,但胃肠道出血风险增加,通常加用质子泵抑制剂(PPI)避免抗血小板治疗所导致的黏膜损害。PPI具有与氯吡格雷相同的肝脏的代谢途径,可能降低氯吡格雷的抗血小板效益并导致不良心血管事件的危险增加。联合应用氯吡格雷与PPI是否影响抗血小板药物治疗效果,尚需大样本研究来证实。

引用

页码：737 / 740

页数：4

共 6 条

[1] ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use: A Report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents.[J].Deepak L. Bhatt;James Scheiman;Neena S. Abraham;Elliott M. Antman;Francis K.L. Chan;Curt D. Furberg;David A. Johnson;Kenneth W. Mahaffey;Eamonn M. Quigley;Robert A. Harrington;Eric R. Bates;Charles R. Bridges;Mark J. Eisenberg;Victor A. Ferrari;Mark A. Hlatky;Sanjay
[2] Initial assessment of clinical impact of a drug interaction between clopidogrel and proton pump inhibitors
Pezalla, Edmund
Day, David
Pulliadath, Indira
[J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2008, 52 (12) : 1038 - 1039
[3] Interaction risk with proton pump inhibitors in general practice:: significant disagreement between different drug-related information sources
Trifiro, Gianluca
Corrao, Salvatore
Alacqua, Marianna
Moretti, Salvatore
Tari, Michele
Caputi, Achille P.
Arcoraci, Vincenzo
[J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2006, 62 (05) : 582 - 590
[4] Pharmacogenomics and Individualized Drug Therapy.[J].Michel Eichelbaum;Magnus Ingelman-Sundberg;William E. Evans.Annual Review of Medicine.2006, 0
[5] Meta-analysis: proton-pump inhibition in high-risk patients with acute peptic ulcer bleeding
Bardou, M
Toubouti, Y
Benhaberou-Brun, D
Rahme, E
Barkun, AN
[J]. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2005, 21 (06) : 677 - 686
[6] 氯吡格雷抵抗及其对策
黄震华
[J]. 中国新药与临床杂志, 2008, (08) : 616 - 620

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