组织型纤溶酶原激活物及其抑制剂与动脉粥样硬化的关系

被引：12

作者：

吴延华

曹勇军

刘春风

机构：

[1] 苏州大学附属第二医院神经内科

来源：

国际脑血管病杂志 | 2007年 / 07期

关键词：

组织型纤溶酶原激活物; 纤溶酶原激活物抑制剂; 动脉粥样硬化; 缺血性脑血管病; 内皮细胞;

D O I：

暂无

中图分类号：

R54 [心脏、血管（循环系）疾病];

学科分类号：

摘要：

组织型纤溶酶原激活物(tPA)和纤溶酶原激活物抑制剂(PAI)是纤溶系统外激活途径的重要活性物质,绝大多数由小血管内皮细胞合成。内皮细胞损伤和功能紊乱是动脉粥样硬化形成的重要始动环节。文章综述了内皮细胞产生的tPA和PAI与动脉粥样硬化和缺血性脑血管病之间的关系。

引用

页码：534 / 537

共 13 条

[1] 独立审查再次证实tPA治疗卒中的益处 [J].

李晓伟 .

国外医学(脑血管疾病分册), 2004, (11) :869-869

[2] 动脉粥样硬化病变组织中PAI-1和uPA抗原表达的变化 [J].

孙东风 ;

诸骏仁 ;

宋后燕 .

中华老年医学杂志, 1997, (06) :32-34

[3] Influence of gender on outcomes after intra-arterial thrombolysis for acute ischemic stroke [J].

Shah, S. H. ;

Liebeskind, D. S. ;

Saver, J. L. ;

Starkman, S. ;

Vinuela, F. ;

Duckwiler, G. ;

Jahan, R. ;

Kim, D. ;

Sanossian, N. ;

Vespa, P. ;

Ovbiagele, B. .

NEUROLOGY, 2006, 66 (11) :1745-1746

[4]

Stroke thrombolysis in the elderly: Risk or benefit?[J] . J Claude Hemphill,Patrick Lyden.Neurology . 2005 (11)

[5] Arterial occlusive lesions recanalize more frequently in women than in men after intravenous tissue plasminogen activator administration for acute stroke [J].

Savitz, SI ;

Schlaug, G ;

Caplan, L ;

Selim, M .

STROKE, 2005, 36 (07) :1447-1451

[6]

Sex-Based Differences in Response to Recombinant Tissue Plasminogen Activator in Acute Ischemic Stroke: A Pooled Analysis of Randomized Clinical Trials[J] . David M. Kent,Lori Lyn Price,Peter Ringleb,Michael D. Hill,Harry P. Selker.Stroke . 2005 (1)

[7] Pharmacoeconomic evaluation of the effects of atorvastatin on early recurrent Ischemic events in acute coronary syndromes [J].

Schwartz, GG ;

Ganz, P ;

Waters, D ;

Arikian, S .

AMERICAN JOURNAL OF CARDIOLOGY, 2003, 92 (09) :1109-1112

[8] Gender differences in coagulation and fibrinolysis in white subjects with acute ischemic stroke [J].

Kain, K ;

Carter, AM ;

Bamford, JM ;

Grant, PJ ;

Catto, AJ .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2003, 1 (02) :390-392

[9]

Abnormal haemorheology, endothelial function and thrombogenesis in relation to hypertension in acute (ictus < 12 h) stroke patients: the West Birmingham Stroke Project[J] . G. Y. H. Lip,A. D. Blann,I. S. Farooqi,J. Zarifis,G. Sagar,D. G. Beevers.Blood Coagulation and Fibrinolysis . 2001 (4)

[10]

Serine proteases and brain damage – is there a link?[J] . Melissa B. Gingrich,Stephen F. Traynelis.Trends in Neurosciences . 2000 (9)

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