依据药物作用的靶分子结构进行新药设计的方法

被引:3
作者
郭春
方林
机构
[1] 沈阳药科大学制药工程学院,沈阳药科大学制药工程学院辽宁沈阳,辽宁沈阳
关键词
药物设计; 靶分子; 配位基; 抑制剂;
D O I
暂无
中图分类号
R914.2 [药物设计];
学科分类号
100705 [微生物与生化药学];
摘要
依据药物作用的靶分子结构进行新药设计 ,作为药物研究中的新方法使新药的研发过程正在从一种偶然性、经验性的过程逐渐走向一种合理的、科学的研发过程。作者在结合国内外有关文献基础上对这一方法的基本原理和基本过程进行综述。
引用
收藏
页数:7
相关论文
共 8 条
[1]
.[J].Gerhard Klebe.Journal of Molecular Medicine.2000, 5
[2]
CAVEAT - A PROGRAM TO FACILITATE THE DESIGN OF ORGANIC-MOLECULES [J].
LAURI, G ;
BARTLETT, PA .
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 1994, 8 (01) :51-66
[3]
FLOG: A system to select ‘quasi-flexible’ ligands complementary to a receptor of known three-dimensional structure.[J].Michael D. Miller;Simon K. Kearsley;Dennis J. Underwood;Robert P. Sheridan.Journal of Computer-Aided Molecular Design.1994, 2
[4]
Structure-based drug design (SBDD): Every structure tells a story....[J].Siegfried H. Reich;Stephen E. Webber.Perspectives in Drug Discovery and Design.1993, 2
[5]
GENSTAR - A METHOD FOR DENOVO DRUG DESIGN [J].
ROTSTEIN, SH ;
MURCKO, MA .
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 1993, 7 (01) :23-43
[6]
SPROUT - A PROGRAM FOR STRUCTURE GENERATION [J].
GILLET, V ;
JOHNSON, AP ;
MATA, P ;
SIKE, S ;
WILLIAMS, P .
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 1993, 7 (02) :127-153
[7]
THE COMPUTER-PROGRAM LUDI - A NEW METHOD FOR THE DENOVO DESIGN OF ENZYME-INHIBITORS [J].
BOHM, HJ .
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 1992, 6 (01) :61-78
[8]
ALADDIN: An integrated tool for computer-assisted molecular design and pharmacophore recognition from geometric; steric; and substructure searching of three-dimensional molecular structures.[J].John H. Drie;David Weininger;Yvonne C. Martin.Journal of Computer-Aided Molecular Design.1989, 3