动脉粥样硬化与脑梗死危险因素

被引：15

作者：

王位

黎红华

机构：

[1] 广州军区武汉总医院

来源：

现代中西医结合杂志 | 2014年 / 23卷 / 01期

关键词：

动脉粥样硬化; 危险因素; 内皮功能; 氧化应激; 炎症;

D O I：

暂无

中图分类号：

R543.5 [动脉疾病];

学科分类号：

摘要：

<正>动脉粥样硬化(AS)是动脉血管壁上一种多因素共同参与的复杂的慢性病变,是心脑血管疾病的重要病理基础,其病因和发病机制尚未完全清楚。但近期研究表明,一些脑梗死危险因素和AS密切相关,及时消除或减少这些危险因素,可减缓AS的进展。现将AS主要发病机制及其与脑梗死危险因素的关系综述如下。1 AS发生的主要机制近年来信号转导和基因调控方面的研究结果揭示炎症和氧化应激是AS发生的两个关键机制,是AS从脂肪条纹形成到斑块破裂和血栓形成这一发展过程的主要环节。而内皮功能障碍是AS的始动环节。1.1炎症与AS在AS斑块形成的起始阶段,血中白细胞

引用

页码：109 / 111

页数：3

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