脑缺血后核酸内切酶对细胞凋亡的作用

被引:2
作者
毕晓莹
丁素菊
机构
[1] 第二军医大学长海医院神经内科
关键词
核酸内切酶; 细胞凋亡; 脑缺血;
D O I
暂无
中图分类号
R743.3 [急性脑血管疾病(中风)];
学科分类号
摘要
近年来 ,人们在缺血性脑血管病的研究中发现了细胞凋亡的证据 ,主要是在半暗带检测到大量被降解的DNA片段 ,在电泳上呈特异性的梯状条带。梯状DNA的出现是内源性核酸内切酶作用的结果。在脑缺血缺氧以及再灌注的病理变化中 ,半暗带的钙离子内流引起钙超载 ,内源性核酸内切酶被激活 ,从不同的作用点不断降解DNA双链 ,导致细胞凋亡。这一作用过程受到基因的调控
引用
收藏
页码:73 / 74
页数:2
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