二肽基肽酶4抑制剂药物相互作用的研究进展

被引：5

作者：

董洁 ^{[1
,2
]}

汤道权 ^{[2
]}

肖冰心 ^{[1
]}

刘云 ^{[1
]}

李艳丽 ^{[1
]}

孙增先 ^{[1
]}

机构：

[1] 连云港市第一人民医院/徐州医科大学附属连云港医院药学部

[2] 徐州医科大学药物分析教研室

来源：

中国药房 | 2017年 / 28卷 / 32期

关键词：

二肽基肽酶4; 二肽基肽酶4抑制剂; 糖尿病; 药物相互作用;

D O I：

暂无

中图分类号：

R969.2 [药物相互作用];

学科分类号：

100706 [药理学];

摘要：

目的:了解二肽基肽酶4（DPP-4）抑制剂药物相互作用的研究进展。方法:查阅近年来国内外相关文献,就DPP-4抑制剂药物相互作用的研究进行归纳和总结。结果与结论:DPP-4抑制剂与大多数药物联用时罕见不良反应发生,无需调整剂量,如二甲双胍、磺脲类、噻唑烷二酮类、格列波糖等传统降糖药,他汀类降脂药,口服避孕药和地高辛等;兰索拉唑、莫沙必利能够增强DPP-4抑制剂的降糖效果;中药辣木提取物和大黄与DPP-4抑制剂存在药物相互作用,能够降低DPP-4抑制剂的疗效,临床联用应谨慎对待;细胞色素P450（CYP）3A4底物或弱效抑制剂辛伐他汀、地尔硫与DPP-4抑制剂联用时无需调整剂量,但与CYP3A4强效抑制剂酮康唑联用时,需按照低剂量给药。尽管DPP-4抑制剂与大多数药物联用具有较好的安全性,但仍需警惕其药物相互作用。

引用

页码：4601 / 4604

页数：4

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