社区获得性肺炎合并与未合并全身炎症反应综合征患者N-末端脑钠肽前体水平变化及临床意义研究

被引：12

作者：

孟爱华

林蕊艳

张虹霞

张淑明

胥振阳

张帅

机构：

[1] 首都医科大学潞河教学医院呼吸与危重症医学科

来源：

中国全科医学 | 2014年 / 17卷 / 02期

关键词：

社区获得性感染; 肺炎; 全身炎症反应综合征; N-末端脑钠肽前体;

D O I：

暂无

中图分类号：

R563.1 [肺炎]; R59 [全身性疾病];

学科分类号：

100201 [内科学];

摘要：

目的探讨社区获得性肺炎(CAP)合并与未合并全身炎症反应综合征(SIRS)患者N-末端脑钠肽前体(NT-proBNP)水平变化及临床意义。方法选择2012年1月—2013年3月我院住院的CAP患者148例,依据是否合并SIRS分为CAP非SIRS组78例和CAP合并SIRS组70例。采用酶联免疫吸附法测定两组患者的血清NT-proBNP水平,并行肺炎严重指数(PSI)评分。结果 CAP合并SIRS组NT-proBNP水平较CAP非SIRS组升高〔188.0(471.8)和62.5(135.3),P=0.009〕。CAP患者NT-proBNP水平与PSI评分呈正相关(r=0.292,P=0.001)。结论 CAP合并SIRS患者NT-proBNP水平升高,依据NT-proBNP水平可区分CAP是否合并SIRS,并可作为CAP患者病情严重程度及预后的判断指标。

引用

页码：144 / 147

页数：4

共 10 条

[1]

社区获得性肺炎诊断和治疗指南.[J]..中华结核和呼吸杂志.2006, 10

[2]

Brain natriuretic peptide measurement in pulmonary medicine [J].

Salerno, Daniel ;

Marik, Paul E. .

RESPIRATORY MEDICINE, 2011, 105 (12) :1770-1775

[3]

Albumin and C-reactive protein have prognostic significance in patients with community-acquired pneumonia [J].

Lee, Jae Hyuk ;

Kim, Jooyeong ;

Kim, Kyuseok ;

Jo, You Hwan ;

Rhee, JoongEui ;

Kim, Tae Youn ;

Na, Sang Hoon ;

Hwang, Seung Sik .

JOURNAL OF CRITICAL CARE, 2011, 26 (03) :287-294

[4]

Prognostic significance of brain natriuretic peptide obtained in the ED in patients with SIRS or sepsis [J].

Chen, Yunxia ;

Li, Chunsheng .

AMERICAN JOURNAL OF EMERGENCY MEDICINE, 2009, 27 (06) :701-706

[5]

Use of B-type natriuretic peptide in the risk stratification of community-acquired pneumonia [J].

Christ-Crain, M. ;

Breidthardt, T. ;

Stolz, D. ;

Zobrist, K. ;

Bingisser, R. ;

Miedinger, D. ;

Leuppi, J. ;

Tamm, M. ;

Mueller, B. ;

Mueller, C. .

JOURNAL OF INTERNAL MEDICINE, 2008, 264 (02) :166-176

[6]

Assessment of B-type natriuretic peptide in patients with pneumonia [J].

Yetkin, O. ;

Hacievliyagil, S. S. ;

Gunen, H. .

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2008, 62 (03) :488-491

[7]

BNP in septic patients without systolic myocardial dysfunction [J].

Shor, Renana ;

Rozenman, Yoseph ;

Bolshinsky, Aharon ;

Harpaz, David ;

Tilis, Yulian ;

Matas, Zipora ;

Fux, Asora ;

Boaz, Mona ;

Halabe, Aaron .

EUROPEAN JOURNAL OF INTERNAL MEDICINE, 2006, 17 (08) :536-540

[8]

Prospective evaluation of pneumonia severity index in hospitalised patients with community-acquired pneumonia [J].

van der Eerden, MM ;

de Graaff, CS ;

Bronsveld, W ;

Jansen, HM ;

Boersma, WG .

RESPIRATORY MEDICINE, 2004, 98 (09) :872-878

[9]

Azithromycin inhibits interleukin-6 but not fibrinogen production in hepatocytes infected with cytomegalovirus and chlamydia pneumoniae.[J].John J.M Bouwman;Frank L.J Visseren;Paul K Bouter;Rob J.A Diepersloot.The Journal of Laboratory and Clinical Medicine.2004, 1

[10]

Increased atrial and brain natriuretic peptides in adults with cyanotic congenital heart disease - Enhanced understanding of the relationship between hypoxia and natriuretic peptide secretion [J].

Hopkins, WE ;

Chen, ZY ;

Fukagawa, NK ;

Hall, C ;

Knot, HJ ;

LeWinter, MM .

CIRCULATION, 2004, 109 (23) :2872-2877

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