L-苯丙氨酸与血管平滑肌细胞增殖(英文)

被引：4

作者：

高平进

朱鼎良

詹一鸣

OLIVIERSTEPIEN

PIERREMARCHE

赵光胜

机构：

[1] 上海第二医科大学附属瑞金医院!上海市高血压研究所，上海,,上海第二医科大学附属瑞金医院!上海市高血压研究所，上海,,上海第二医科大学附属瑞金医院!上海市高血压研究所，上海,,Pharmacologie,CNRSURA!Paris，France,Pharmacologie,CNRSURA!

来源：

生理学报 | 1998年 / 04期

关键词：

L-苯丙氨酸; 血管平滑肌细胞; 细胞增殖;

D O I：

暂无

中图分类号：

R331 [血液与循环生理];

学科分类号：

1001 ;

摘要：

本文用氚标胸腺嘧啶核苷掺入DNA合成法测定自发性高血压大鼠（SHR）与正常对照鼠的培养主动脉血管平滑肌细胞（VSMC）增殖，观察L-苯丙氨酸对细胞增殖、细胞生长及原癌基因c-fos、c－myc表达的影响。结果显示：（1）L-苯丙氨酸剂量依赖性地抑制血清、碱性成纤维细胞生长因子及凝血酶诱导的DNA合成；（2）L-苯丙氨酸剂量依赖性地抑制细胞对血清的增殖反应；（3）L-苯丙氨酸抑制血清诱导的c－fos、c－myc的表达；（4）L-酪氨酸，L-组氨酸及D-苯丙氨酸不能产生类似L-苯丙氨酸的抑制作用。这些资料说明L-苯丙氨酸具有直接、特异性的抗VSMC增殖作用，提示L-苯丙氨酸在SHR大鼠中的抗高血压作用可能与血管平滑肌细胞增殖受抑有关。

引用

页码：401 / 408

页数：8

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