抗血小板药物治疗反应多样性临床检测和处理的中国专家建议

被引:89
作者
韩雅玲
机构
[1] 中华医学会心血管病学分会会
[2] 中华心血管病杂志编辑委员会
[3] 沈阳军区总医院
关键词
D O I
暂无
中图分类号
R541.4 [冠状动脉(粥样)硬化性心脏病(冠心病)];
学科分类号
摘要
<正>血小板的黏附、活化和聚集在急性冠状动脉综合征(acute coronary syndromes,ACS)及经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)的病理生理过程中起重要作用。阿司匹林和P2Y12受体抑制剂(如氯吡格雷)作为两类最常用的抗血小板药物,是目前ACS和(或)PCI术后预防血栓事件的基石。研究发现,个体对抗血小板治疗的反应性差异与血栓、出血等不良事件显著相关。通过血小
引用
收藏
页码:986 / 991
页数:6
相关论文
共 10 条
  • [1] 2013 ESC guidelines on the management of stable coronary artery disease
    Montalescot, Gilles
    Sechtem, Udo
    Achenbach, Stephan
    Andreotti, Felicita
    Budaj, Andrzej
    Bugiardini, Raffaele
    Crea, Filippo
    Cuisset, Thomas
    Di Mario, Carlo
    Rafael Ferreira, J.
    Gersh, Bernard J.
    Gitt, Anselm K.
    Hulot, Jean-Sebastien
    Marx, Nikolaus
    Opie, Lionel H.
    Pfisterer, Matthias
    Prescott, Eva
    Ruschitzka, Frank
    Sabate, Manel
    Senior, Roxy
    Taggart, David Paul
    van der Wall, Ernst E.
    Vrints, Christiaan J. M.
    Knuuti, Juhani
    Valgimigli, Marco
    Bueno, Hector
    Claeys, Marc J.
    Donner-Banzhoff, Norbert
    Erol, Cetin
    Frank, Herbert
    Funck-Brentano, Christian
    Gaemperli, Oliver
    Gonzalez-Juanatey, Jose R.
    Hamilos, Michalis
    Hasdai, David
    Husted, Steen
    James, Stefan K.
    Kervinen, Kari
    Kolh, Philippe
    Kristensen, Steen Dalby
    Lancellotti, Patrizio
    Maggioni, Aldo Pietro
    Piepoli, Massimo F.
    Pries, Axel R.
    Romeo, Francesco
    Ryden, Lars
    Simoons, Maarten L.
    Sirnes, Per Anton
    Steg, Ph. Gabriel
    Timmis, Adam
    [J]. EUROPEAN HEART JOURNAL, 2013, 34 (38) : 2949 - +
  • [2] Platelet reactivity and clinical outcomes after coronary artery implantation of drug-eluting stents (ADAPT-DES): a prospective multicentre registry study[J] . Gregg W Stone,Bernhard Witzenbichler,Giora Weisz,Michael J Rinaldi,Franz-Josef Neumann,D Christopher Metzger,Timothy D Henry,David A Cox,Peter L Duffy,Ernest Mazzaferri,Paul A Gurbel,Ke Xu,Helen Parise,Ajay J Kirtane,Bruce R Brodie,Roxana Mehran,Thomas D Stuckey.The Lancet . 2013 (9892)
  • [3] Consensus and Update on the Definition of On-Treatment Platelet Reactivity to Adenosine Diphosphate Associated With Ischemia and Bleeding
    Tantry, Udaya S.
    Bonello, Laurent
    Aradi, Daniel
    Price, Matthew J.
    Jeong, Young-Hoon
    Angiolillo, Dominick J.
    Stone, Gregg W.
    Curzen, Nick
    Geisler, Tobias
    ten Berg, Jurrien
    Kirtane, Ajay
    Siller-Matula, Jolanta
    Mahla, Elisabeth
    Becker, Richard C.
    Bhatt, Deepak L.
    Waksman, Ron
    Rao, Sunil V.
    Alexopoulos, Dimitrios
    Marcucci, Rossella
    Reny, Jean-Luc
    Trenk, Dietmar
    Sibbing, Dirk
    Gurbel, Paul A.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2013, 62 (24) : 2261 - 2273
  • [4] High On-Aspirin Platelet Reactivity and Clinical Outcome in Patients With Stable Coronary Artery Disease: Results From ASCET (Aspirin Nonresponsiveness and Clopidogrel Endpoint Trial)[J] . Journal of the American Heart Association . 2012 (3)
  • [5] Point-of-care genetic testing for personalisation of antiplatelet treatment (RAPID GENE): a prospective, randomised, proof-of-concept trial[J] . Jason D Roberts,George A Wells,Michel R Le May,Marino Labinaz,Chris Glover,Michael Froeschl,Alexander Dick,Jean-Francois Marquis,Edward O’Brien,Sandro Goncalves,Irena Druce,Alexandre Stewart,Michael H Gollob,Derek YF So.The Lancet . 2012 (9827)
  • [6] Antiplatelet Drug Response Status Does Not Predict Recurrent Ischemic Events in Stable Cardiovascular Patients: Results of the Antiplatelet Drug Resistances and Ischemic Events Study[J] . Circulation . 2012 (25)
  • [7] Consensus and Future Directions on the Definition of High On-Treatment Platelet Reactivity to Adenosine Diphosphate
    Bonello, Laurent
    Tantry, Udaya S.
    Marcucci, Rossella
    Blindt, Ruediger
    Angiolillo, Dominick J.
    Becker, Richard
    Bhatt, Deepak L.
    Cattaneo, Marco
    Collet, Jean Philippe
    Cuisset, Thomas
    Gachet, Christian
    Montalescot, Gilles
    Jennings, Lisa K.
    Kereiakes, Dean
    Sibbing, Dirk
    Trenk, Dietmar
    Van Werkum, Jochem W.
    Paganelli, Franck
    Price, Matthew J.
    Waksman, Ron
    Gurbel, Paul A.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 56 (12) : 919 - 933
  • [8] Cilostazol in addition to aspirin and clopidogrel improves long-term outcomes after percutaneous coronary intervention in patients with acute coronary syndromes: A randomized, controlled study[J] . Yaling Han,Yi Li,Shouli Wang,Quanmin Jing,Zhulu Wang,Dongmei Wang,Qingfen Shu,Xiuying Tang.American Heart Journal . 2009 (4)
  • [9] Thrombelastography: Current clinical applications and its potential role in interventional cardiology[J] . A. R. Hobson,R. A. Agarwala,R. A. Swallow,K. D. Dawkins,N. P. Curzen.Platelets . 2006 (8)
  • [10] Variability in platelet responsiveness to clopidogrel among 544 individuals[J] . Victor L. Serebruany,Steven R. Steinhubl,Peter B. Berger,Alex I. Malinin,Deepak L. Bhatt,Eric J. Topol.Journal of the American College of Cardiology . 2004 (2)