秀丽隐杆线虫在药物筛选中的应用

被引：35

作者：

周雨朦 ^{[1
,2
]}

陈代杰 ^{[1
,2
]}

机构：

[1] 中国医药工业研究总院

[2] 上海医药工业研究院创新药物与制药工艺国家重点实验室

来源：

上海医药 | 2011年 / 32卷 / 11期

关键词：

秀丽隐杆线虫; 模型; 药物筛选; 药靶筛选;

D O I：

暂无

中图分类号：

R965.1 [药物筛选和实验模型];

学科分类号：

100706 [药理学];

摘要：

秀丽隐杆线虫在药物和靶蛋白筛选方面越来越受到药物学家的重视,已形成了较为完善的药物筛选技术平台。本文以新药的发现为目标,介绍线虫作为新药筛选模型的特点、研究现状及该模型在新药发现中的应用。

引用

页码：566 / 571

页数：6

共 10 条

[1]

Lipid uptake assays..Verwaerde P;Anthonissen C;Deprez B;.WO2001088533.2001,

[2]

Daf-2;an insulinreceptor-like gene that regulates longevity and diapause inCaenorhabditis elegans..Kimura KD;Tissenbaum HA;Liu Y;Ruvkun G;.Science.1997, 5328

[3]

Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans [J].

Collins, James J. ;

Evason, Kimberley ;

Kornfeld, Kerry .

EXPERIMENTAL GERONTOLOGY, 2006, 41 (10) :1032-1039

[4]

C-elegans models of age-associated neurodegenerative diseases:: Lessons from transgenic worm models of Alzheimer's disease [J].

Link, Christopher D. .

EXPERIMENTAL GERONTOLOGY, 2006, 41 (10) :1007-1013

[5]

The Wnt-dependent signaling pathways as target in oncology drug discovery [J].

Janssens, Nico ;

Janicot, Michel ;

Perera, Tim .

INVESTIGATIONAL NEW DRUGS, 2006, 24 (04) :263-280

[6]

A role for SIR-2.1 regulation of ER stress response genes in determining C-elegans life span [J].

Viswanathan, M ;

Kim, SK ;

Berdichevsky, A ;

Guarente, L .

DEVELOPMENTAL CELL, 2005, 9 (05) :605-615

[7]

The worm has turned – microbial virulence modeled in Caenorhabditis elegans.[J].Costi D. Sifri;Jakob Begun;Frederick M. Ausubel.Trends in Microbiology.2005, 3

[8]

Regulation of aging and innate immunity in C-elegans [J].