β-环糊精衍生物对黄酮类药物的增溶作用

被引：16

作者：

王茹林

杨郁

双少敏

潘景浩

机构：

[1] 山西大学化学化工学院

[2] 山西大学化学化工学院太原

[3] 现在山西医科大学基础医学院化学教研室

[4] 太原

来源：

应用化学 | 2002年 / 07期

基金：

国家教育部优秀青年教师资助计划;

关键词：

相溶解度; β-环糊精衍生物; 黄酮类药物; 增溶作用;

D O I：

暂无

中图分类号：

O629 [天然化合物];

学科分类号：

070303 ; 081704 ;

摘要：

The inclusion interactions between flavonoids and β cyclodextrin( β CD) and its derivatives have been studied by a phase solubility method. The phase solubility graphs showed that the 1∶1 inclusion compounds were formed beween β CD and rutin, qucertin and morin respectively. The compounds appeared to be a type of A L inclusion. β CD derivatives have stronger binding capacity than β CD. The enhanced solubility of compounds decreased in the order methyl β CD>hydroxypropyl β CD> β CD. The highest solubility was obtained in methyl β CD inclusion complex with qucertin in level of 50 times than that in water.

引用

页码：702 / 704

页数：3