24例卵巢异位子宫内膜恶变的临床病理分析及恶变机理

被引:9
作者
杨开选
孙亮
徐炼
万宇
宋波
姚先莹
机构
[1] 四川大学华西第二医院病理科
关键词
子宫内膜异位症; 异位内膜恶变; 恶变机理;
D O I
暂无
中图分类号
R737.31 [卵巢肿瘤];
学科分类号
100214 ;
摘要
[目的]探讨卵巢异位子宫内膜恶变的临床病理特征。[方法]回顾性分析24例卵巢异位子宫内膜恶变的临床病理资料。[结果]卵巢异位子宫内膜恶变24例,其中23例(95.83%)为异位子宫内膜腺上皮恶变,腺癌形成;1例为异位内膜肉瘤变,宫内膜间质细胞肉瘤形成。[结论]当卵巢宫内膜囊肿近期迅速增大,疼痛加剧,CA125升高≥正常值2倍,提示恶变的可能。腺上皮非典型增生是异位宫内膜恶变的的癌前病变,其恶变与激素分泌紊乱,相关酶及其受体调节失调,相关基因表达异常等因素有关。
引用
收藏
页码:2790 / 2791
页数:2
相关论文
共 8 条
[1]  
Ali-Fehmi R,Khalifeh I,Bandyopadhyay S,et al.Patterns of loss of heterozygosity at10q23.3and microsatellite instability in en-dometriosis,atypical endometriosis,and ovarian carcinoma arising in association with endometriosis. International Journal of Gynecological Pathology . 2006
[2]  
Oral E,Ilvan S,Tustas E,et al.Prevalence of endometriosis in malignant epithelial ovary tumours. European Journal of Obstet-rics and Gynecology and Reproductive Biology . 2003
[3]  
Ogawa S,Kaku T,Amada S,et al.Ovrian endometriosis associat-ed with ovrian carcinoma:a clinicopathological and immunohisto-chemical study. Gynecologic Oncology . 2000
[4]  
Saing dela Cuesta R,Izquierdo M,Canamero M,et al.Increased prevalence of P53overexpression from typical endometriosis to atyp-ical endometriosis and ovrian cancer associated with endometriosis. European Journal of Obstetrics Gynecology and Reproductive Biology . 2004
[5]  
Akahane T,Sekizawa A,Okuda T,et al.Disappearance of steroid hormone dependency during malignant transformation of ovrian clear cell cancer. International Journal of Gynecological Pathology . 2005
[6]  
Modesitt S C,Tortolero L G,Robinson J B,et al.Ovarian and ex-traovrian endometriosis associated cancer. Obstetrics and Gynecology . 2002
[7]  
Rajesh V,Terrance R,Janesh K,et al.Endometriosis and the neoplastic process. Society for Reproduction and Fertility . 2004
[8]  
Benoit L,Arnould L,Cheynel N,et al.Malignant extraovrian en-dometriosis:a review. European Journal of Surgical Oncology . 2006