线粒体缺陷与阿尔采末病

[1] Inhibitionof energe metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative. Gabuzda D,Busciglio J,Chen LB,et al. Journal of Biological Chemistry . 1994

[2] Cortical cytochrome oxidase activity is reduced in Alzheimer’sdisease. Mutisya EM,Bowling AC,Beal MF. Journal of Neurochemistry . 1994

[3] Transfer ofbeta - amyloid precursor protein gene using adenovirus vector causes mitochondrial abnormalities incultured normal hum an m uscle. Askanas V,McFerrin J,Baqu S,et al. Proc Natl Acad SciU SA . 1996

[4] Cybridsin Alzheimer’s disease: acellular m odel ofthe disease. Swerdlow RH,Parks JK,Parker WD Jr,et al. Neurology . 1997

[5] Decreased expression of nuclear and mitochondrialDNAencoded genes of oxidative phosphorylation inassociation neocortex in Alzheimer disease. Chandrasekaran K,Rapoport SI,Brady DR,et al. Brain Research Molecular Brain Research . 1997

[6] Effect of sodiu mazide on motor activity , motor coordination ,andlearning. Lalonde R,Joyal CC,Beaudin S. Pharmacol Biochem Behav . 1997

[7] ApparentmtDNA heteroplasmy in Alzheimer’s disease patients and in normals due to PCR amplification ofnucleusembedded mtDNApseudogenes. Hirano M,Shtilbans A,Mayeux R,et al. Proceedings of the National Academy of Sciences of the United States of America . 1997

[1] Inhibitionof energe metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative. Gabuzda D,Busciglio J,Chen LB,et al. Journal of Biological Chemistry . 1994

[2] Cortical cytochrome oxidase activity is reduced in Alzheimer’sdisease. Mutisya EM,Bowling AC,Beal MF. Journal of Neurochemistry . 1994

[3] Transfer ofbeta - amyloid precursor protein gene using adenovirus vector causes mitochondrial abnormalities incultured normal hum an m uscle. Askanas V,McFerrin J,Baqu S,et al. Proc Natl Acad SciU SA . 1996

[4] Cybridsin Alzheimer’s disease: acellular m odel ofthe disease. Swerdlow RH,Parks JK,Parker WD Jr,et al. Neurology . 1997

[5] Decreased expression of nuclear and mitochondrialDNAencoded genes of oxidative phosphorylation inassociation neocortex in Alzheimer disease. Chandrasekaran K,Rapoport SI,Brady DR,et al. Brain Research Molecular Brain Research . 1997

[6] Effect of sodiu mazide on motor activity , motor coordination ,andlearning. Lalonde R,Joyal CC,Beaudin S. Pharmacol Biochem Behav . 1997

[7] ApparentmtDNA heteroplasmy in Alzheimer’s disease patients and in normals due to PCR amplification ofnucleusembedded mtDNApseudogenes. Hirano M,Shtilbans A,Mayeux R,et al. Proceedings of the National Academy of Sciences of the United States of America . 1997