血管成形术后再狭窄实验模型

被引：15

作者：

郗永安

汪丽蕙

机构：

[1] 北京

[2] 北京医科大学第一临床医学院心内科

来源：

中国介入心脏病学杂志 | 1995年 / 04期

关键词：

内皮剥脱; 再狭窄; 动脉粥样硬化; 动脉硬化; VSMC; 实验模型; 冠状动脉; 动脉病变; 动脉壁;

D O I：

暂无

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

1002 ; 100201 ;

摘要：

<正>近年,经皮冠状动脉再通的机械方法日臻完善.多数狭窄病变可经球囊扩张、粥样斑块切除、腔内支架、激光、超声、微波、射频和热成形予以治疗.不幸的是术后再狭窄(RS)率高达50%,其远期效果依然有限.RS病理生理与防治措施的深入研究已成为介入性心脏病学领域中亟待解决的一大课题.鉴于临床试验影响因素众多,这一研究很大程度上有赖于动物模型的建立和应用.本文对不同动物模型的特征进行了比较,重点讨论了动脉口径、形态结构、不同种系动物对自发和食物诱导动脉病变的易感性,受损内膜增生性质及若干实用问题.对体外实验和具体药物在不同动物模型与临床试验中的疗效也做了相应介绍.

引用

页码：47 / 49

页数：3

共 15 条

[1]

Vascular remodeling:Honey,I think.I shrunk the artery. Isner JM. Circulation . 1994

[2]

Persistent dysfunction of regenerated endothelium after banlloon angioplasty of rabbit iliac artery. Weidinger FF,Mclenachan JM,Cybulsky MI,et al. Circulation . 1990

[3]

Majack RA,Reidy MA.Basic fibroblast growth factor stimulates endothelial regrowth and proliferation in denuded arteries. Linder v. The Journal of Clinical Investigation . 1990

[4]

Experimental models of coronary artery restenosis. Muller DWM,Ellis SG,Topol EJ.et al. Journal of the American College of Cardiology . 1992

[5]

A new approach for local intravascular drug delivery:Iontophoretic balloon. Fernandez-Ortiz A,Meyer BJ,Mailhac A,et al. Circulation . 1994

[6]

Kinetics of cellular proliferation after arterial injury.I.Smooth muscle cell growth in the absence of endothelium. Clowes AW,Reidy MA,Clowes MM,et al. Laboratory Investigation . 1983

[7]

A comparision of structural features of the walls of coronary artery from 10 different species. Sims FH. The Journal of Pathology . 1989

[8]

Prospects for site-specific delivery of pharmacologic and molecular therapies. Riessen R,Isner JM. Journal of the American College of Cardiology . 1993

[9]

Coronary restenosis:Prospects for solution and new perspectives from a porcine model. Schwartz RS,Edwards WD,Antoniades LC,et al. Mayo Clinic Proceedings . 1993

[10]

Restenosis after balloon angioplasty:A practical proliferation model in porcine coronary artery. Schwartz RS,Murphy JG,Edwards WD,et al. Circulation . 1990

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