STUDIES ON THE TOXICITY OF QINGHAOSU AND ITS DERIVATIVES

被引：10

作者：

China Cooperative Research Group on Qinahaosu and Its Derivatives as Antimalarials ^{[1
]}

机构：

[1] China Cooperative Research Group on Qinahaosu and Its Derivatives as Antimalarials

来源：

JournalofTraditionalChineseMedicine | 1982年 / 01期

关键词：

STUDIES ON THE TOXICITY OF QINGHAOSU AND ITS DERIVATIVES; ITS;

D O I：

10.19852/j.cnki.jtcm.1982.01.006

中图分类号：

学科分类号：

摘要：

This paper reports general and special to-xicological experiments on Qinghaosu and itsderivatives.Results point to the superiority ofQinghaosu and its derivatives over chloroquinein such respects as therapeutic index,marginof safety and side effects.It is pertinent there-fore to recommend these compounds for clinicaltrial as antimalarials.The main toxic effects of Qinghaosu weremanifested on the hemopoietic system,especial-ly the erythroid series,and the myocardium wassomewhat involved.These toxic reactions werehowever reversible.The teratogenicity experi-ments in mice and rats showed both Qinghaosuand artemether to be embryo-toxic,and clinicaltrials should take into account these toxic ef-fects.Further studies with various other animalspecies should be aimed at discovering whetherspecies differences exist.

引用

页码：31 / 38

页数：8