高危型人乳头瘤病毒检测在宫颈未明确诊断意义的不典型鳞状上皮细胞中的价值

被引：18

作者：

杜蓉 ^{[1
,2
]}

陈志芳 ^{[1
,2
]}

丁岩 ^{[1
]}

机构：

[1] 新疆医科大学第一附属医院

[2] 中南大学

来源：

实用妇产科杂志 | 2011年 / 27卷 / 08期

关键词：

未明确诊断意义的不典型鳞状上皮细胞; 人乳头瘤病毒; 分型检测;

D O I：

暂无

中图分类号：

R737.33 [子宫肿瘤];

学科分类号：

摘要：

目的:评价人乳头瘤病毒(HPV)分型检测在宫颈未明确诊断意义的不典型鳞状上皮细胞(ASCUS)分层处理中的临床价值。方法:对宫颈液基细胞涂片结果判读为ASCUS的351例患者行高危型HPV分型检测、阴道镜下宫颈活组织检查及宫颈管内膜诊刮术。分析ASCUS患者病理检查结果与HPV分型检测结果的关系。结果:①351例ASCUS病例中,病理证实宫颈上皮内瘤变(CIN)共69例(69/351,19.6%),其中CINⅡ及以上检出26例,占总数的7.4%(26/351)。②351例ASCUS病例中,高危型HPV阳性率为55.6%(195/351)。高危型HPV阳性及HPV感染阴性组CINⅡ及以上病变检出率分别为11.8%(23/195)、2.1%(3/142),相比差异有统计学意义(P<0.05)。高危型HPV阳性对检出CINⅡ及以上病变的敏感度、特异度、阳性预测值及阴性预测值分别为88.46%,48.00%,11.79%,98.07%。③195例高危型阳性病例中,HPV16亚型及58亚型阳性率分别为45.6%及21.0%。HPV16亚型及58亚型阳性组中CINⅡ及以上检出率分别为7.7%(15/195)、2.6%(5/195),相比差异有统计学意义(P<0.05)。结论:高危型HPV检测在ASCUS患者分层处理中有重要价值,尤其是HPV16亚型阳性患者需立即行阴道镜检查。低危型阳性及HPV感染阴性患者仍需密切随访。

引用

页码：603 / 606

页数：4

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