非酒精性脂肪肝发病机制——“二次打击”学说研究进展

被引：117

作者：

董姝 ^{[1
,2
,3
]}

刘平 ^{[1
,2
,3
,4
]}

孙明瑜 ^{[1
,2
,4
]}

机构：

[1] 上海中医药大学附属曙光医院

[2] 上海中医药大学肝病研究所肝肾疾病病证教育部重点实验室

[3] 上海中医药大学

[4] 上海高校中医内科学E-研究院

来源：

临床肝胆病杂志 | 2012年 / 07期

关键词：

脂肪肝; 二次打击;

D O I：

暂无

中图分类号：

R575.5 [肝代谢障碍];

学科分类号：

1002 ; 100201 ;

摘要：

非酒精性脂肪肝(NAFLD)是肝脏系统中一类最为普遍的肝脏疾病。近年来,随着生活水平的提高,其发病率也逐年上升。由于NAFLD发病的隐匿性,其具体的发病机制目前仍不清楚,"二次打击"学说在其中的重要地位已得到一致认可。现就NAFLD发病机制与"二次打击"相关的细胞因子、代谢以及免疫方面等因素作一综述。

引用

页码：551 / 555

页数：5

共 30 条

[1] Adiponectin,a key adipokine in obesity related liver diseases [J].

Christa Buechler ;

Josef Wanninger ;

Markus Neumeier .

World Journal of Gastroenterology, 2011, 17 (23) :2801-2811

[2]

Roles of liver innate immune cells in nonalcoholic fatty liver disease[J]. Yu-Tao Zhan, Department of Gastroenterology and Hepatology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China Wei An, Department of Cell Biology, Capital Medical University, Beijing 100069, China.World Journal of Gastroenterology. 2010(37)

[3]

Pathogenesis and management issues for non-alcoholic fatty liver disease[J]. Marko Duvnjak,Ivan Leroti,Neven Bari,Vedran Tomai,Lucija Virovi Juki,Vedran Velagi.World Journal of Gastroenterology. 2007(34)

[4] Research on the protection effect of pioglitazone for non-alcoholic fatty liver disease (NAFLD)in rats [J].

XU Ping ZHANG Xingguo LI Youming YU Chaohui XU Lei XU Genyun Department of Gastroenterology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou China Department of Pharmacology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou China Center of Clinical Laboratory the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou China .

Journal of Zhejiang University Science(Life Science), 2006, (08) :627-633

[5]

The 5-lipoxygenase/leukotriene pathway in obesity, insulin resistance, and fatty liver disease[J] . Marcos Martínez-Clemente,Joan Clària,Esther Titos.Current Opinion in Clinical Nutrition and Metabolic Care . 2011 (4)

[6] Increased prevalence of non-alcoholic fatty liver disease in European women with a history of gestational diabetes [J].

Forbes, S. ;

Taylor-Robinson, S. D. ;

Patel, N. ;

Allan, P. ;

Walker, B. R. ;

Johnston, D. G. .

DIABETOLOGIA, 2011, 54 (03) :641-647

[7]

Effects of a high fat diet on liver mitochondria: increased ATP-sensitive K + channel activity and reactive oxygen species generation[J] . Journal of Bioenergetics and Biomembranes . 2010 (3)

[8] Oxidative stress induced by high-glucose diet in liver of C57BL/6J mice and its underlying mechanism [J].

Du, Dan ;

Shi, Yong-Hui ;

Le, Guo-Wei .

MOLECULAR BIOLOGY REPORTS, 2010, 37 (08) :3833-3839

[9] Circulating osteocalcin concentrations are associated with parameters of liver fat infiltration and increase in parallel to decreased liver enzymes after weight loss [J].

Fernandez-Real, J. M. ;

Ortega, F. ;

Gomez-Ambrosi, J. ;

Salvador, J. ;

Fruehbeck, G. ;

Ricart, W. .

OSTEOPOROSIS INTERNATIONAL, 2010, 21 (12) :2101-2107

[10]

Methionine limitation results in increased hepatic FAS activity, higher liver 18:1 to 18:0 fatty acid ratio and hepatic TAG accumulation in Atlantic salmon, Salmo salar[J] . Amino Acids . 2010 (2)

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