氧化应激反应与膝关节骨性关节炎的相关性探究

被引：14

作者：

马俊 ^{[1
]}

左传 ^{[1
]}

马勇胜 ^{[1
]}

潘洪志 ^{[2
]}

杨卫良 ^{[1
]}

机构：

[1] 哈尔滨医科大学附属第一医院骨二科

[2] 哈尔滨医科大学公共卫生学院

来源：

现代生物医学进展 | 2016年 / 16卷 / 03期

关键词：

氧化应激反应; 膝关节骨性关节炎; 过氧化损伤;

D O I：

10.13241/j.cnki.pmb.2016.03.025

中图分类号：

R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

目的:了解膝关节骨性关节炎患者机体的氧化应激状态,探讨氧化应激反应与膝关节骨性关节炎发生、发展的关系。方法:收集膝关节骨性关节炎患者及健康人群的血清,采用分光光度法测定和比较其SOD、GSH-Px、MDA水平。结果:与健康对照人群相比,膝关节骨性关节炎患者体内SOD、GSH-Px酶类抗氧化剂活力显著增强(P<0.05);MDA脂质过氧化损伤产物明显降低(P<0.05)。结论:膝关节骨性关节炎患者体内氧化还原状态发生了改变,可能处于抗氧化应激的慢性代偿状态;氧化应激反应参与了骨性关节炎的发生、发展过程。

引用

页码：500 / 503

页数：4

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