缺血/再灌注损伤时丝裂原活化蛋白激酶信号转导通路的变化

被引：13

作者：

蔡琪

李晓玫

王海燕

机构：

[1] 北京医科大学第一医院肾内科暨肾脏病研究所!北京,北京医科大学第一医院肾内科暨肾脏病研究所!北京,北京医科大学第一医院肾内科暨肾脏病研究所!北京

来源：

中国病理生理杂志 | 2000年 / 12期

关键词：

局部缺血; 再灌注损伤; 有丝分裂原;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

100104 ;

摘要：

Mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinases (ERKs), c-Jun NH2-terminal kinases (JNKs) and p38 MAPK, play an important role in transducting environmental stimuli to the transcriptional machinery in the nucleus in mammalian cells by virtue of their ability to phosphorylate and regulate the activity of various transcription factors. It was recently found that the changes in activity of MAPKs occurred during ischemia/reperfusion, but the biological significance of the changes was still controversial.

引用

页码：88 / 90

页数：3

共 14 条

[1]

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[2]

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[3]

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[5]

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[6]

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[7]

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[8]

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[9]

Oxidative stress induces DNA fragmentation and caspase activation via the c - Jun NH2 -terminal kinase pathway in H9c2 cardiac muscle cells. Turner NA,Xia F,Azhar G,et al. Journal of Molecular and Cellular Cardiology . 1998

[10]

PKC-dependent activation of p44/p42MAPKs during myocardial ischemia-reperfusion in conscious rabbits. Ping P,Zhang J,cao X,et al. American Journal of Physiology . 1999

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