肿瘤坏死因子超家族与脑梗死相关性的研究进展

被引:5
作者
何洋
刘广志
机构
[1] 北京大学人民医院神经内科
关键词
脑梗死; 肿瘤坏死因子类; 颈动脉疾病; 动脉粥样硬化;
D O I
暂无
中图分类号
R743.3 [急性脑血管疾病(中风)];
学科分类号
1002 ;
摘要
<正>脑梗死作为一种常见的脑血管疾病,多发于中老年,致残率高且易复发,在其多种危险因素中颈动脉粥样硬化已被证实为重要致病因素之一。肿瘤坏死因子超家族(TNFSF)是一大类由免疫细胞分泌具有多种生物学效应的细胞因子,不仅介导抗肿瘤,亦可调节机体免疫功能、参与炎性反应。近来研究发现其多个成员参与了动脉粥样硬化的发生发展过程,并与脑梗死的发生及其再灌注损伤关系密切。我们对
引用
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页码:889 / 891
页数:3
相关论文
共 18 条
[1]   急性动脉粥样硬化性脑梗死患者外周血单核细胞4-1BB配体表达水平的变化 [J].
刘广志 ;
苗丹 ;
高旭光 .
临床神经病学杂志, 2011, 24 (01) :8-10
[2]   Low serum TNF-related apoptosis-inducing ligand (TRAIL) levels are associated with acute ischemic stroke severity [J].
Kang, Yang Ho ;
Park, Min-Gyu ;
Noh, Kyung-Ha ;
Park, Hae Rim ;
Lee, Hye Won ;
Son, Seok Man ;
Park, Kyung-Pil .
ATHEROSCLEROSIS, 2015, 240 (01) :228-233
[3]  
Roles of ligands from the TNF superfamily in B cell development, function, and regulation[J] . William A. Figgett,Fabien B. Vincent,Damien Saulep-Easton,Fabienne Mackay.Seminars in Immunology . 2014 (3)
[4]   Genetic deletion or TWEAK blocking antibody administration reduce atherosclerosis and enhance plaque stability in mice [J].
Sastre, Cristina ;
Fernandez-Laso, Valvanera ;
Madrigal-Matute, Julio ;
Munoz-Garcia, Begona ;
Moreno, Juan A. ;
Pastor-Vargas, Carlos ;
Llamas-Granda, Patricia ;
Burkly, Linda C. ;
Egido, Jesus ;
Martin-Ventura, Jose L. ;
Blanco-Colio, Luis M. .
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2014, 18 (04) :721-734
[5]  
Evidence for involvement of the CD40/CD40L system in post-stroke epilepsy[J] . Bikui Zhang,Min Chen,Heng Yang,Tian Wu,Cuizhu Song,Ren Guo.Neuroscience Letters . 2014
[6]   CD40 ligand as a potential biomarker for atherosclerotic instability [J].
Wang, Jing-Hua ;
Zhang, Yong-Wei ;
Zhang, Ping ;
Deng, Ben-Qiang ;
Ding, Suju ;
Wang, Zhong-Kui ;
Wu, Tao ;
Wang, Jian .
NEUROLOGICAL RESEARCH, 2013, 35 (07) :693-700
[7]   Plasma osteoprotegerin levels increase with the severity of cerebral artery atherosclerosis [J].
Kim, Jinkwon ;
Song, Tae-Jin ;
Yang, Seung-Hee ;
Lee, Ok-Hee ;
Nam, Hyo Suk ;
Kim, Young Dae ;
Kim, Eun Hee ;
Lee, Hye Sun ;
Nam, Chung Mo ;
Heo, Ji Hoe .
CLINICAL BIOCHEMISTRY, 2013, 46 (12) :1036-1040
[8]  
Protein Therapeutics Targeted at the TNF Superfamily[J] . Carl F. Ware.Advances in Pharmacology . 2013
[9]  
Structural Basis of Signal Transduction in the TNF Receptor Superfamily[J] . Jixi Li,Qian Yin,Hao Wu.Advances in Immunology . 2013
[10]   Single nucleotide polymorphism of CD40 in the 5′-untranslated region is associated with ischemic stroke [J].
Ma, Ying ;
Wang, Shun-Xian ;
Liu, Yun ;
Peng, Guo-Guang ;
Wang, Xiao-Ming ;
Zhang, Bo ;
Wu, Bi-Hua ;
Yu, Ju-Ming .
GENE, 2013, 529 (02) :257-261