p38丝裂原活化蛋白激酶的功能与调控机制

被引：54

作者：

庄秋宇

刘俊

韩家淮

机构：

[1] 厦门大学生命科学学院

来源：

中国细胞生物学学报 | 2013年 / 35卷 / 02期

关键词：

p38丝裂原活化蛋白激酶; 信号通路; 细胞外刺激;

D O I：

暂无

中图分类号：

Q26 [细胞生物化学];

学科分类号：

071013 [干细胞生物学];

摘要：

丝裂原活化蛋白激酶家族可以在一系列细胞外刺激下调控细胞的行为。作为该家族的四个亚家族之一,p38亚族在许多生理过程中扮演着重要角色。p38信号通路可以在紫外照射、热击、高渗透压、炎症因子、生长因子等细胞外刺激时被激活,调控细胞分化、细胞周期、炎症反应等多种生理过程。文章重点讨论了p38亚族各个成员的特性、该信号通路的组成部分、调控机制以及生物学功能。另外,还分析了p38与其他信号通路的联系以及对一些生理过程的影响。

引用

页码：123 / 133

页数：11

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