轻度脑损伤病人任务态fMRI脑区激活:元分析

被引:8
作者
张俊 [1 ,2 ]
张恒柱 [2 ]
张洪英 [2 ]
王海丽 [1 ,2 ]
王润培 [2 ]
李育平 [2 ]
魏民 [2 ]
刘晓光 [2 ]
王杏东 [2 ]
董伦 [2 ]
机构
[1] 大连医科大学研究生院
[2] 扬州大学临床医学院神经外科
关键词
颅脑损伤,创伤性,轻度; 任务态fMRI; 激活似然估计; Meta分析;
D O I
暂无
中图分类号
R445.2 [核磁共振成像]; R651.15 [];
学科分类号
100231 [临床病理学];
摘要
目的运用激活似然估计(activation likelihood estimation,ALE)元分析探讨轻度创伤性脑损伤(mild traumatic brain injury,mTBI)病人认知相关脑区激活特点,并试图阐明mTBI病人认知功能改变的神经机制。方法系统检索中文及外文数据库,检索时间从建库开始至2020年3月2日。运用软件Ginger-ALE 3.0.2进行坐标统一化与元分析。计算出的脑区ALE分布图通过Mango软件与Brainnet Review软件呈现。结果共纳入7项研究,其中mTBI病例174例,健康对照者140例。元分析结果显示:与健康被试者相比,mTBI病人左前叶角回、左枕叶视觉联合、左侧中脑、右颞叶角回、右侧小脑扁桃体等脑区激活增强,而右背外侧前额叶、左小脑前叶、左背外侧前额叶、右侧额中回、右侧后扣带回等脑区激活减弱。进一步联合分析发现:右侧额中回背外侧前额叶为共激活减弱脑区。结论右侧额中回背外侧前额叶激活减弱是区分mTBI病人与健康被试者的主要脑区。此外,认知障碍可能与右侧额中回背外侧前额叶激活减弱有关,这可能与控制注意力的神经网络的募集能力下降有关。
引用
收藏
页码:105 / 109
页数:5
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