益生菌及其细胞组分的免疫调节作用

被引：10

作者：

宗莉

杨立明

张传卫

康玉茹

机构：

[1] 中国科学院兰州化学物理研究所

来源：

微生物学杂志 | 2006年 / 02期

关键词：

益生菌; 细胞组分; 免疫调节;

D O I：

暂无

中图分类号：

Q935 [微生物生理学];

学科分类号：

071005 ; 100705 ;

摘要：

益生菌对肠道黏膜系统的调节作用是应用益生菌提高宿主抵抗某些病源菌感染及预防肿瘤发生的基础。但是,益生菌的作用机理目前还不完全清楚。益生菌细胞壁组分可能是引发免疫反应的功能性物质,而构成各种益生菌细胞壁组分的差异可能是益生菌免疫调节作用存在菌种特异性的主要原因。肠道派伊尔斑外层的M细胞是介导益生菌或其细胞组分进入上皮下层的主要通道,进入上皮下层的益生菌或其细胞残片可以被黏膜免疫系统的树突状细胞(DC)或巨噬细胞吞噬,并呈递给淋巴细胞。益生菌及其细胞组分在黏膜局部刺激黏膜免疫系统,也可以引起系统免疫反应,但其通过局部免疫刺激引起系统免疫反应的机理目前还不清楚。研究益生菌细胞组分构成和益生菌免疫激活作用之间的关系,及由局部免疫刺激引发系统免疫反应的机理是益生菌免疫刺激作用机理研究需要解决的两大问题。

引用

页码：92 / 95

页数：4

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