血管生成相关因子在肿瘤中的表观遗传学变化

被引：7

作者：

吕天娇

冯炜炜

机构：

[1] 复旦大学附属妇产科医院妇产科

来源：

肿瘤 | 2012年 / 32卷 / 04期

关键词：

肿瘤; 血管生成; 表观遗传学; 甲基化; 乙酰化;

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 [肿瘤学];

摘要：

在肿瘤的发生、发展和转移过程中,新生血管的生成起着至关重要的作用,此过程受到相关血管生成因子的调控,这种调控既包括遗传学方面的,也包括表观遗传学方面的。与遗传学的变化不同,表观遗传学变化大多是可逆的。研究者正试图应用DNA甲基化转移酶抑制剂和组蛋白去乙酰化酶抑制剂来拮抗肿瘤及其血管的生成,从而指导肿瘤的临床治疗。本文综述了近年来受表观遗传调控的肿瘤血管生成相关因子的研究进展,阐述了其在肿瘤血管新生过程中表观遗传的调控作用。

引用

页码：301 / 307

页数：7

共 9 条

[1]

CDH13 and FLBN3 Gene Methylation are Associated with Poor Prognosis in Colorectal Cancer [J].

Wang, Zhu ;

Yuan, Xin ;

Jiao, Nanlin ;

Zhu, Hui ;

Zhang, Youwei ;

Tong, Jiandong .

PATHOLOGY & ONCOLOGY RESEARCH, 2012, 18 (02) :263-270

[2]

No evidence for DNA methylation of von Hippel-Lindau ubiquitin ligase complex genes in breast cancer [J].

Huang, Katie T. ;

Dobrovic, Alexander ;

Fox, Stephen B. .

BREAST CANCER RESEARCH AND TREATMENT, 2010, 124 (03) :853-856

[3]

Hypermethylation and Transcriptional Downregulation of the TIMP3 Gene is Associated with Allelic Loss on 22q12.3 and Malignancy in Meningiomas [J].

Barski, Dimitri ;

Wolter, Marietta ;

Reifenberger, Guido ;

Riemenschneider, Markus J. .

BRAIN PATHOLOGY, 2010, 20 (03) :623-631

[4]

von Hippel–Lindau Methylation Status in Patients with Multiple Myeloma: A Potential Predictive Factor for the Development of Bone Disease.[J].Eleftheria Hatzimichael;George Dranitsaris;Aggeliki Dasoula;Leonidas Benetatos;Justin Stebbing;Tim Crook;Konstantinos L. Bourantas.Clinical Lymphoma & Myeloma.2009, 3

[5]

Different angiogenic potential in low and high grade sporadic clear cell renal cell carcinoma is not related to alterations in the von Hippel–Lindau gene.[J].Marcella M. Baldewijns;Iris J.H. van Vlodrop;Kim M. Smits;Peter B. Vermeulen;Gert G. Van den Eynden;Fiona Schot;Tania Roskams;Hein van Poppel;Manon van Engeland;Adriaan P. de Bru?ne.Cellular Oncology.2009, 5

[6]

Aberrant Promoter Methylation of Sparc in Ovarian Cancer [J].

Socha, Matthew J. ;

Said, Neveen ;

Dai, Yan Shan ;

Kwong, Joseph ;

Ramalingan, Preetha ;

Trieu, Vuong ;

Desai, Niel ;

Mok, Samuel C. ;

Motamed, Kouros .

NEOPLASIA, 2009, 11 (02) :126-U37

[7]

Hypermethylation of the RECK gene predicts poor prognosis in oral squamous cell carcinomas [J].

Long, Nguyen Khanh ;

Kato, Keizo ;

Yamashita, Tomomi ;

Makita, Hiroki ;

Toida, Makoto ;

Hatakeyama, Daijiro ;

Hara, Akira ;

Mori, Hideki ;

Shibata, Toshiyuki .

ORAL ONCOLOGY, 2008, 44 (11) :1052-1058

[8]

Epidermal growth factor-containing fibulin-like extracellularmatrix protein1;EFEMP1;a novel tumor-suppressor gene detected in hepatocellular carcinoma using double combination array analysis..NOMOTO S;KANDA M;OKAMURA Y;et al;.Ann Surg Oncol.2010, 03

[9]

Role of RECK methylation in gastric cancer and its clinical significance [J].

Du, Yun-Yi ;

Dai, Dong-Qiu ;

Yang, Zhi .

WORLD JOURNAL OF GASTROENTEROLOGY, 2010, 16 (07) :904-908

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