细胞角蛋白CK19在口腔粘膜癌变过程中的变化

被引：13

作者：

聂敏海

钟利

曾光明

李秉琦

机构：

[1] 泸州医学院附属医院口腔内科,泸州医学院附属医院传染科,四川大学华西口腔医学院口腔内科,四川大学华西口腔医学院口腔内科四川,四川

来源：

中华口腔医学杂志 | 2002年 / 03期

关键词：

角蛋白; 口腔粘膜; 癌前状态;

D O I：

暂无

中图分类号：

R739.8 [口腔、颌面部肿瘤];

学科分类号：

100214 ;

摘要：

目的　探讨口腔粘膜癌变过程中CK19的变化。方法　收集正常口腔粘膜、上皮单纯增生、上皮异常增生和口腔鳞癌活检标本共 5 3例 ,用免疫组化、电泳和Western杂交方法研究上皮中CK19的表达。结果　CK19表达于有上皮异常增生的复层鳞状上皮基底上层和口腔鳞癌尤其是低分化鳞癌的癌细胞中。随病变程度加重 ,CK19表达的阳性率、表达强度和占细胞角蛋白的构成比显著增加。结论　CK19表达于口腔粘膜上皮的基底上层可作为口腔癌前病变的辅助标志 ,CK19表达增加是口腔粘膜癌变过程中的早期事件

引用

页码：30 / 33+86

页数：5

共 8 条

[1]

A new small (40kd) keratin filament protein made by some cultured human squmous cell carcinomass. Wu YJ,Rheinwald JG. Cell . 1981

[2]

Suprabasal 40 kd keratin(K19) expression as an immunohistologic marker of premalignancy in oral epithelium. Lindberg K,Rheinwald JG. American Journal of Pathology . 1989

[3]

The catalog of human cytokeratins: patterns of expression in normal epthelia, tumors and cultured cells. Moll R,Franke WW,Schiller DL,et al. Cell . 1982

[4]

Markers for dysplasia of the upper aerodigestive tract.Suprabasal expression of PCNA, p53, and CK19 in alcohol-fixed, embedded tissue. Coltrera MD,Zarbo RJ,Sakr WA,et al. American Journal of Pathology . 1992

[5]

Immunolocalization of keratin polypeptides in human epidermis using monoclonal antibodies. Woodcock-Mitchell J,Eichner R,Nelson WG,et al. The Journal of Cell Biology . 1982

[6]

Alteration of cytokeratin expression in oral lichen planus. Boisnic S,Ouhayoun JP,Branchet MC,et al. Oral Surg Oral Med Oral Pathol Oral Radiol Endod . 1995

[7]

Cytokeratin expression in normal and (pre) malignant head and neck epithelia: an overview. van der Velden LA,Schaafsma HE,Manni JJ,et al. Head and Neck . 1993

[8]

New approaches and concepts in the study of differentiation of oral epithelia. Dale BA,Salonen J,Jones AH. Critical Reviews in Oral Biology and Medicine . 1990

← 1 →