急性心肌梗死患者早期血浆脑钠素与左室重塑的关系

被引:14
作者
王晓阳
丁文惠
张宝娓
田洪森
曹静
张钧华
唐朝枢
机构
[1] 河南省洛阳市中心医院心内科!河南洛阳
[2] 北京医科大学第一医院心内科!北京
[3] 北京医科大学第一医院心
关键词
急性心肌梗死; 脑钠素; 左室重塑;
D O I
暂无
中图分类号
R542.22 [];
学科分类号
摘要
目的 探讨急性心肌梗死 (AMI)早期血浆脑钠素与左室重塑的关系。方法  44例AMI患者分为依那普利组及常规治疗组 ,采用放射免疫法测定入院后 14d内血浆脑钠素水平 ;超声心动图测定同期及 3个月左室舒张末容积指数 (LVEDVI)、左室收缩末容积指数 (LVESVI)及左室射血分数 (LVEF)。结果 常规治疗组入院后即刻血浆脑钠素水平较健康对照组明显升高 (P <0 .0 1) ,5、14d较入院即刻进一步升高 (P <0 .0 5 )。AMI患者 5、14d血浆脑钠素水平与同期及 3个月LVEDVI、LVESVI正相关 (P <0 .0 5 ,0 .0 1)。与常规治疗组相比 ,依那普利组脑钠素与心室容积指数一致性下降。结论 AMI后早期血浆脑钠素升高与左室重塑密切相关。
引用
收藏
页码:10 / 13
页数:4
相关论文
共 9 条
[1]  
Late effects of acute infarct dilation on heart size: a two dimensional echocardiographic study〔J〕. Erlebacher JA,Weiss JL,Eaton LW et al. The American Journal of Cardiology . 1982
[2]  
Natriuretic peptides: Physiology, therapeutic potential, and risk stratification in ischemic heart disease〔J〕. Stein BC,Levin RI. American Heart Journal . 1998
[3]  
Rapid Ventricular induction of brain natriuretic peptide gene expression in experimental acute myocardial infarction〔J〕. Hama N,Itoh H,Shirakami G et al. Circulation . 1995
[4]  
Left ventricular end-systolic volume as the major determinant of survival after recovery from myocardial infartion〔J〕. White HD,Norris RM,Brown MA et al. Circulation . 1987
[5]  
Alterations in cardiac gene expression during ventricular remodeling following experimental myocardial infarction〔J〕. Jain MG,Huang B,Jain P et al. Journal of Molecular and Cellular Cardiology . 1998
[6]  
Brain natriuretic peptide as a marker for hypertensive left ventricular hypertrophy: changes during 1-year antihypertensive therapy with angiotensin-converting enzyme inhibitor〔J〕. Kohno M,Hoyio T,Yokokawa K et al. The American Journal of Medicine . 1995
[7]  
Plasma brain natriuretic peptide as an indicator for angiotensin-converting-enzyme inhibition after myocardial infarction〔J〕. Motwani JG,Mcalpine H,Kennedy N et al. The Lancet . 1993
[8]  
Brain natriuretic peptide as a novel cardiac hormone in humans〔J〕. Mukoyama M,Nakao K,Hosoda K et al. The Journal of Clinical Investigation . 1991
[9]  
Plasma brain natriuretic peptide is a biochemical marker for the prediction of progressive ventricular remodeling after acute myocardial infarction〔J〕. Nagaya N,Nishikimi T,Goto Y et al. American Heart Journal . 1998