脑缺血再灌注损伤的炎症反应机制研究进展

被引：97

作者：

王萍

张密霞

庄朋伟

卢志强

韩娟

张艳军

机构：

[1] 天津中医药大学

来源：

天津中医药大学学报 | 2014年 / 33卷 / 05期

关键词：

脑缺血再灌注; 炎症; 细胞因子; 炎症信号通络;

D O I：

暂无

中图分类号：

R743.31 [短暂性脑缺血];

学科分类号：

100204 [神经病学];

摘要：

<正>大脑是人体对缺血、缺氧最为敏感的器官,脑缺血可导致脑细胞坏死或凋亡,在治疗时间窗内及时地溶栓以及迅速有效的重建微血管侧枝循环,恢复缺血区及半暗带的血液再灌注是脑缺血的最佳治疗方法[1],然而缺血后血流的再通可导致缺血再灌注损伤。脑缺血再灌注时,在缺血灶局部存在大量炎症因子,并且炎症细胞的激活、浸润及黏附分子的合成分泌呈一种相互增强相互促进的级联反应[2],并通过一定的炎症信号通路使脑组织由缺血

引用

页码：317 / 320

页数：4

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