cAMP反应元件结合蛋白与神经退行性疾病

被引:4
作者
光红梅
杜冠华
机构
[1] 中国医学科学院药物研究所
关键词
cAMP反应元件结合蛋白; 神经退行性疾病; 磷酸化;
D O I
暂无
中图分类号
R741 [神经病学];
学科分类号
1002 ;
摘要
cAMP反应元件结合蛋白(cAMP response elem ent b ind-ing prote in,CREB)是位于细胞核内的转录因子。CREB的活性受到信号通路中许多因子的调控。CREB活化后与真核生物靶基因CRE序列结合并调节其转录,发挥多种生物学效应。在中枢神经系统,CREB调节着神经细胞生长发育,参与神经细胞突触可塑性、长时程记忆的形成过程。CREB参与阿尔采末病、血管性痴呆、亨廷顿舞蹈病及H IV-相关痴呆等神经退行性疾病的病理生理机制研究也取得了进展,成为以CREB作为靶点控制神经退行性疾病病程的理论基础。
引用
收藏
页码:262 / 266
页数:5
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