人血浆白蛋白的生理功能及临床应用

被引：25

作者：

张敏

机构：

[1] 四川省医学科学院·四川省人民医院药剂科

来源：

四川生理科学杂志 | 2011年 / 33卷 / 01期

关键词：

人血白蛋白; 生理功能; 临床应用;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

人血浆中的白蛋白是血浆中含量最丰富的蛋白质,占血清总蛋白量的50%以上,分子量约为6.9万道尔顿。人血白蛋白制剂具有重要的生理功能和临床应用,目前较为公认的应用指征为:大面积烧伤24 h后、急性创伤性休克、急性呼吸窘迫综合征、血液置换治疗、肾透析、严重的低蛋白血症伴腹水、急性肝功能衰竭伴肝昏迷等。但在实际的临床实践中,由于对人血白蛋白的生理功能、药理作用及用药指征不够了解,致使临床上普遍存在白蛋白不合理应用的现象,本文参考相关文献,就其生理功能、药理作用、临床应用及不合理用药现象等作一简述。

引用

页码：36 / 38

页数：3

共 11 条

[1] 白蛋白临床不合理应用及其使用指征 [J].

吴国豪 .

药物不良反应杂志, 2008, (04) :261-263

[2]

Morbidity in hospitalized patients receiving human albumin:a meta-analysis of randomized,controlled trials. Vincent JL,Navickis RJ,Wilkes MM. Critical Care Medicine . 2004

[3]

C-reactive protein and al-bumin as predictors of all-cause and cardiovascular mortalityin chronic kidney disease. Menon V,Greene T,Wang X,et al. Kidney International . 2005

[4]

A comparison of albumin and saline for fluid resuscitation in the intensive care unit. Finfer S,Bellomo R,Bovce N,et al. New England Journal of Medicine, The . 2004

[5]

Debate:Albumin administration should be avoided in the critically ill. Thomas B,Pulimood,GilbertR Park,et al. CritCare . 2000

[6]

Low diastolic blood pressure, hypoalbuminemia, and risk of death in a cohort of chronic haemodialysis patients. K Iseki,F Miyasato,K Tokuyama. Kidney International . 1997

[7]

Effects of a hydroxyeth-ylstarch solution on plasma colloid osmotic pressure in acutely ill pa-tients. Mbaba Mena J,De Backer D,Vincent JL. Acta Anaesthesiologica . 2000

[8]

Effects of albumin supplementation onmicrovascular permeability in septic patients. Margarson MP,Soni NC. Journal of Applied Physiology . 2002

[9]

Albumin administration:what is the evidence of clinical benefit?A systematic review of ran-domized controlled trials. Haynes GR,Navickis RJ,Wilkes MM. European Journal of Anaesthesiology . 2003

[10]

Human albumin administration in critically ill patients: systematic review of randomized controlled trials. Cochrane Injuries Group Albumin Reviewers. British Medical Journal . 1998

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