冠心病合并代谢综合征患者血脂特点及其与冠脉病变程度的关系

被引：11

作者：

朱梅

薛桥

郭新红

机构：

[1] 解放军总医院老年心血管病研究所

来源：

心血管康复医学杂志 | 2009年 / 18卷 / 02期

关键词：

冠状动脉疾病; 代谢综合征X; 高脂血症;

D O I：

暂无

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）]; R589 [代谢病];

学科分类号：

摘要：

目的:探讨冠心病合并代谢综合征(MS)患者血脂特点及MS对冠脉病变程度的影响。方法:冠状动脉造影确诊为冠心病的患者258例,分为MS以及非MS组,计算其gensini评分并测定血清脂质谱以及其他相关危险因素,评价冠心病合并MS患者血脂特点及其与冠脉病变严重程度的关系。结果:冠心病合并MS组与不合并MS组患者比较,冠脉病变的程度和范围均明显加重(P<0.01),MS组血浆甘油三酯(TG)、总胆固醇(TC)、载脂蛋白B(ApoB)以及ApoB/A1比值较未合并MS组的明显增高(P<0.05～<0.01),高密度脂蛋白-胆固醇(HDL-C)显著低于对照组(P<0.01),而ApoA1以及低密度脂蛋白-胆固醇(LDL-C)并无显著差异,操作特征曲线(ROC)的曲线下面积(AUC)最大者为TG(0.732),其次为ApoB、LDL-C/HDL-C、HDL-C以及ApoB/ApoA1。结论:冠心病合并MS患者存在多种脂质参数异常,与冠状动脉损伤范围以及狭窄密切相关,TG、TC、HDL-C以及ApoB是评价MS较好的脂质参数。

引用

页码：112 / 115

页数：4

共 10 条

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