MnTBAP对脑挫伤大鼠脑组织丙二醛、超氧化物歧化酶和一氧化氮的影响

被引：3

作者：

刁尧

刘新宇

赵文瑾

刘杰

赵恂

于成国

机构：

[1] 中国医科大学实验技术中心

来源：

中国现代医学杂志 | 2011年 / 21卷 / 29期

关键词：

MnTBAP; 脑挫伤; 超氧化物歧化酶; 丙二醛; 一氧化氮;

D O I：

暂无

中图分类号：

R965 [实验药理学];

学科分类号：

100602 ; 100706 ;

摘要：

目的观察超氧化物歧化酶类似物锰四(4-苯甲酸)卟啉(MnTBAP)对脑挫伤大鼠脑组织中丙二醛(MDA)、超氧化物歧化酶(SOD)及一氧化氮(NO)含量的影响,探讨MnTBAP对脑挫伤后继发性损伤的保护作用。方法 SD大鼠60只,雌雄不拘,分为假手术对照组、损伤组和MnTBAP治疗组。用自由落体方法制备大鼠脑挫伤模型,损伤组术后立即腹腔注射生理盐水,治疗组术后立即腹腔注射MnTBAP(10 mg/kg体质量)。于术后1、6、12和24 h取挫伤侧脑组织标本,测定SOD、MDA和NO活性和含量。结果与假手术对照组相比,损伤组脑组织SOD水平降低(P<0.01),MDA和NO水平增高(P<0.01)。与损伤组相比,MnTBAP治疗组脑组织SOD水平增高(P<0.05),相反,MDA和NO水平降低(P<0.01)。结论 MnTBAP具有抗氧化清除自由基功能,能有效提高挫伤后脑组织SOD含量,减少MDA和NO含量,对继发性脑损伤具有保护作用。

引用

页码：3615 / 3617+3626 +3626

页数：4

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