卒中治疗的抗氧化策略

被引：12

作者：

Isabelle Margaill ^{[1
]}

Michel Plotkine ^{[1
]}

Dominique Lerouet ^{[1
]}

赵峰 ^{[2
]}

姜亚军 ^{[2
]}

机构：

[1] From the Laboratoire de Pharmacologie(UPRES EA ),Université

来源：

国际脑血管病杂志 | 2006年 / 06期

关键词：

局灶性脑缺血; 自由基; 氧化应激;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

摘要：

众所周知,自由基生成过多会在许多种疾病如脑缺血中导致细胞损伤。大量研究对局灶性脑缺血中这种氧化应激和抗氧化策略的有效性进行了探讨,本文对其中的一部分进行阐述。除应用转基因小鼠外,这些抗氧化策略可分为3类:(1)抑制自由基产生;(2)清除自由基;(3)应用模拟内源性抗氧化物酶活性的药物增加自由基降解。最后,对已经结束或正在进行的评价卒中患者抗氧化剂疗效的临床试验进行回顾。结果显示抗氧化剂是非常有前景的治疗缺血性卒中的药物。

引用

页码：401 / 412

页数：12

共 50 条

[1]

When Melatonin Gets on Your Nerves: Its Beneficial Actions in Experimental Models of Stroke[J] . Russel J. Reiter,Dun-xian Tan,Josefa Leon,ülkan Kilic,Ertugrul Kilic.Experimental Biology and Medicine . 2005 (2)

[2]

Prophylactic use of melatonin protects against focal cerebral ischemia in mice: role of endothelin converting enzyme‐1[J] . ErtugrulKilic,ülkanKilic,Russel J.Reiter,Claudio L.Bassetti,Dirk M.Hermann.Journal of Pineal Research . 2004 (4)

[3]

Free radical scavenger, edaravone, in stroke with internal carotid artery occlusion[J] . Kazunori Toyoda,Kenichiro Fujii,Masahiro Kamouchi,Hiroshi Nakane,Shoji Arihiro,Yasushi Okada,Setsuro Ibayashi,Mitsuo Iida.Journal of the Neurological Sciences . 2004 (1)

[4] Single-dose ebselen does not afford sustained neuroprotection to rats subjected to severe focal cerebral ischemia [J].

Salom, JB ;

Pérez-Asensio, FJ ;

Burguete, MC ;

Marín, N ;

Pitarch, C ;

Torregrosa, G ;

Romero, FJ ;

Alborch, E .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2004, 495 (01) :55-62

[5] Neuroprotective effects of the free radical scavenger Edaravone (MCI-186) in mice permanent focal brain ischemia [J].

Shichinohe, H ;

Kuroda, S ;

Yasuda, H ;

Ishikawa, T ;

Iwai, M ;

Horiuchi, M ;

Iwasaki, Y .

BRAIN RESEARCH, 2004, 1029 (02) :200-206

[6]

Oxyresveratrol ( trans -2,3′,4,5′-tetrahydroxystilbene) is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia[J] . Shaida A Andrabi,Mariarosa G Spina,Peter Lorenz,Uwe Ebmeyer,Gerald Wolf,Thomas F.W Horn.Brain Research . 2004 (1)

[7]

Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat[J] . Brain Research . 2004 (1)

[8]

Temporal changes in cerebral antioxidant enzyme activities after ischemia and reperfusion in a rat focal brain ischemia model: effect of dietary fish oil[J] . Smi Choi-Kwon,Kyung-Ae Park,Hee-Joo Lee,Myung-Sook Park,Joung-Hee Lee,Sang-Eun Jeon,Myoung-Ae Choe,Kyoung-Chan Park.Developmental Brain Research . 2004 (1)

[9]

Polymorphonuclear neutrophils contribute to infarction and oxidative stress in the cortex but not in the striatum after ischemia–reperfusion in rats[J] . Virginie Beray-Berthat,Nicole Croci,Michel Plotkine,Isabelle Margaill.Brain Research . 2003 (1)

[10] The antioxidant EPC-K1 ameliorates brain injury by inhibiting lipid peroxidation in a rat model of transient focal cerebral ischaemia [J].

Kato, N ;

Yanaka, K ;

Nagase, S ;

Hirayama, A ;

Nose, T .

ACTA NEUROCHIRURGICA, 2003, 145 (06) :489-493

← 1 2 3 4 5 →