Sirt1与心肌保护

被引：15

作者：

尹茂山 ^{[1
,2
]}

牟艳玲 ^{[2
,3
]}

机构：

[1] 济南大学山东省医学科学院医学与生命科学学院

[2] 山东省医学科学院药物研究所

[3] 山东省罕少见病重点实验室

来源：

生命科学 | 2015年 / 27卷 / 05期

关键词：

Sirt1; 信号通路; 作用机制; 心肌保护;

D O I：

10.13376/j.cbls/2015081

中图分类号：

R363 [病理生理学];

学科分类号：

100103 [病原生物学];

摘要：

Sirt1是依赖烟碱胺腺嘌呤二核苷酸(NAD+)的第III类组蛋白去乙酰化酶。在心肌细胞中,Sirt1通过去乙酰化相关因子增强细胞抵抗氧化应激的能力、减少细胞凋亡、减轻炎症反应、调节能量代谢、协调心脏舒缩功能,发挥心肌保护作用。现主要对Sirt1的相关信号通路及其心肌保护作用研究进展进行综述。

引用

页码：601 / 608

页数：8

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