E-cadherin、N-cadherin在乳腺癌中表达变化及意义附视频

被引：6

作者：

孙建平

李锋

曹玉文

蒋金芳

万国兴

李文琴

机构：

[1] 石河子大学医学院病理系

来源：

石河子大学学报(自然科学版) | 2013年 / 04期

关键词：

乳腺癌; EMT; E-cadherin; N-cadherin;

D O I：

10.13880/j.cnki.65-1174/n.2013.04.004

中图分类号：

R737.9 [乳腺肿瘤];

学科分类号：

摘要：

为观察乳腺浸润性导管癌中,EMT相关表型分子E-cadherin、N-cadherin蛋白表达变化,探讨EMT与乳腺癌变、分级相关性。采用收集70例乳腺癌组织和20例癌旁正常组织制作组织芯片,应用免疫组化EnVision法检测E-cadherin、N-cadherin蛋白表达。结果显示,乳腺浸润性导管癌E-cadherin阳性表达明显降低,同时N-cadherin阳性表达明显升高,E-cadherin与N-cadherin表达呈显著相关性(r=0.405,P<0.05);乳腺癌高、中、低分化组织中,E-cadherin阳性表达逐渐升高,同时N-cadherin阳性表达逐渐降低。由此可知,乳腺癌细胞存在EMT,EMT参与乳腺癌变过程,并与乳腺癌恶性程度有相关性。

引用

页码：473 / 476

页数：4

共 12 条

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