内皮细胞损伤在糖尿病肾病发病机制中的作用

被引：161

作者：

赵鹏鸣

王俭勤

梁耀军

机构：

[1] 兰州大学第二医院肾内科

来源：

中国糖尿病杂志 | 2016年 / 24卷 / 02期

关键词：

肾小球内皮细胞; 糖尿病肾病; 蛋白尿; 发病机制;

D O I：

暂无

中图分类号：

R587.2 [糖尿病性昏迷及其他并发症]; R692.9 [其他疾病];

学科分类号：

100201 [内科学]; 100221 [泌尿外科学];

摘要：

DN是糖尿病慢性微血管并发症之一,也是引起终末期肾病和导致糖尿病患者死亡的主要原因。肾小球内皮细胞是肾小球滤过屏障的重要组分,因其与循环物质直接接触,易受血糖、血脂及炎症因子损伤的影响。高血糖状态下,蛋白激酶C(PKC)通路、多元醇通路和氧化应激(OS)被激活,并产生过量的AGEs和活性氧簇(ROS),损伤内皮一氧化氮合酶(eNOS),降低一氧化氮的生成,同时高血糖刺激RAS产生大量血管紧张素Ⅱ损伤内皮细胞,此外,肾小球足细胞与内皮细胞相互作用,进一步加重内皮细胞损伤。本文就内皮细胞损伤在DN发病机制中的作用做一综述。

引用

页码：169 / 172

页数：4

共 13 条

[1]

Role of Endothelial Nitric Oxide Synthase in Diabetic Nephropathy: Lessons from Diabetic eNOS Knockout Mice.[J].Takamune Takahashi;Raymond C. Harris;Ronald G. Tilton.Journal of Diabetes Research.2014,

[2]

Diabetic kidney disease: from physiology to therapeutics [J].

Mora-Fernandez, Carmen ;

Dominguez-Pimentel, Virginia ;

Muros de Fuentes, Mercedes ;

Gorriz, Jose L. ;

Martinez-Castelao, Alberto ;

Navarro-Gonzalez, Juan F. .

JOURNAL OF PHYSIOLOGY-LONDON, 2014, 592 (18) :3997-4012

[3]

Renal Endothelial Dysfunction in Diabetic Nephropathy.[J].Huifang Cheng;Raymond C. Harris.Cardiovascular & Hematological Disorders-Drug Targets.2014, 1

[4]

High glucose induces activation of the local renin-angiotensin system in glomerular endothelial cells [J].

Peng, Hui ;

Xing, Yan-Fang ;

Ye, Zeng-Chun ;

Li, Can-Ming ;

Luo, Peng-Li ;

Li, Ming ;

Lou, Tan-Qi .

MOLECULAR MEDICINE REPORTS, 2014, 9 (02) :450-456

[5]

Molecular mechanisms of diabetic kidney disease [J].

Reidy, Kimberly ;

Kang, Hyun Mi ;

Hostetter, Thomas ;

Susztak, Katalin .

JOURNAL OF CLINICAL INVESTIGATION, 2014, 124 (06) :2333-2340

[6]

The Endothelium in Diabetic Nephropathy [J].

Gilbert, Richard E. .

CURRENT ATHEROSCLEROSIS REPORTS, 2014, 16 (05)

[7]

Dual protein kinase C alpha and beta inhibitors and diabetic kidney disease: a revisited therapeutic target for future clinical trials [J].

Koya, Daisuke .

JOURNAL OF DIABETES INVESTIGATION, 2014, 5 (02) :147-148

[8]

Impact of gender and dialysis modality on early mortality risk in diabetic ESRD patients: data from a large single center cohort [J].

Serafinceanu, C. ;

Neculaescu, C. ;

Cimponeriu, D. ;

Timar, R. ;

Covic, A. C. .

INTERNATIONAL UROLOGY AND NEPHROLOGY, 2014, 46 (03) :607-614

[9]

Endothelial-Podocyte Crosstalk: The Missing Link Between Endothelial Dysfunction and Albuminuria in Diabetes [J].

Siddiqi, Ferhan S. ;

Advani, Andrew .

DIABETES, 2013, 62 (11) :3647-3655

[10]

The glomerulus – a view from the inside – the endothelial cell.[J].Agnes B. Fogo;Valentina Kon.International Journal of Biochemistry and Cell Biology.2010, 9

← 1 2 →