塞来昔布治疗疼痛及炎症临床前期及临床研究

被引:15
作者
Elizabeth Tindall
机构
[1] 美国俄勒冈州波特兰医学会
关键词
塞来昔布; 环氧化酶; 骨关节炎; 类风湿关节炎; COX2特异性; 药物不良反应;
D O I
暂无
中图分类号
R971.1 [];
学科分类号
摘要
塞来昔布是一个环氧化酶 2 (COX 2 )特异性抑制剂 ,是治疗骨关节炎和类风湿关节炎的抗炎镇痛药 ,而伴随治疗的不良作用则是由于其对COX 1的抑制作用。临床试验表明 :塞来昔布较安慰剂明显有效 ,且与传统NSAID的萘普生疗效相当 ,安全且耐受性好 ,不影响血小板聚集 ,也未出现胃肠道溃疡。
引用
收藏
页码:574 / 577
页数:4
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