糖尿病肾病发病机制中各种炎性因子的作用

被引：29

作者：

陈白帆

任建功

机构：

[1] 兰州大学第二医院糖尿病科

来源：

医学综述 | 2012年 / 18卷 / 05期

关键词：

糖尿病; 糖尿病肾病; 炎性因子;

D O I：

暂无

中图分类号：

R587.2 [糖尿病性昏迷及其他并发症];

学科分类号：

100201 [内科学];

摘要：

糖尿病肾病(DN)是糖尿病严重的微血管并发症之一,目前认为与糖代谢紊乱、血流动力学改变、凝血机制异常、蛋白质的非酶糖基化、氧化应激、细胞因子表达异常及遗传背景等多种因素有关。其中炎性反应是DN病变过程中的一个重要环节,炎性因子与脂肪内分泌、氧化应激、免疫系统相互作用引起胰岛素抵抗和B细胞结构与功能障碍,导致2型糖尿病。现就炎性因子在DN发病机制中的作用予以综述。

引用

页码：747 / 749

页数：3

共 16 条

[1]

Tumor necrosis factor-α as a therapeutic target for diabetic nephropathy [J].

Navarro-Gonzalez, Juan F. ;

Jarque, Ana ;

Muros, Mercedes ;

Mora, Carmen ;

Garcia, Javier .

CYTOKINE & GROWTH FACTOR REVIEWS, 2009, 20 (02) :165-173

[2]

Merit of Astragalus polysaccharide in the improvement of early diabetic nephropathy with an effect on mRNA expressions of NF-κB and IκB in renal cortex of streptozotoxin-induced diabetic rats [J].

Zhang, Ying-Wen ;

Wu, Chao-Yan ;

Cheng, Hei-Tang .

JOURNAL OF ETHNOPHARMACOLOGY, 2007, 114 (03) :387-392

[3]

Association of low-grade inflammation with nephropathy in type 2 diabetic patients: Role of elevated CRP-levels and 2 different gene-polymorphisms of proinflammatory cytokines [J].

Abrahamian, H. ;

Endler, G. ;

Exner, M. ;

Mauler, H. ;

Raith, M. ;

Endler, L. ;

Rumpold, H. ;

Gerdov, M. ;

Mannhalter, C. ;

Prager, R. ;

Irsigler, K. ;

Wagner, O. F. .

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 2007, 115 (01) :38-41

[4]

Leukocyte–endothelial cell adhesion molecule 1 (LECAM-1) polymorphism is associated with diabetic nephropathy in type 2 diabetes mellitus.[J].Kenji Kamiuchi;Goji Hasegawa;Hiroshi Obayashi;Akane Kitamura;Michiyo Ishii;Miho Yano;Takahiro Kanatsuna;Toshikazu Yoshikawa;Naoto Nakamura.Journal of Diabetes and Its Complications.2002, 5

[5]

Inhibitory effect of troglitazone on tumor necrosis factor alpha-induced expression of monocyte chemoattractant protein-1 in human mesangial cells [J].