异丙酚及咪唑安定和硫喷妥钠对鼠局灶脑缺血/再灌注损伤的影响

被引：11

作者：

陈莲华

贡沁燕

俞彰

陈英子

肖常思

机构：

[1] 复旦大学医学院眼耳鼻喉科医院麻醉科

[2] 复旦大学基础医学院药理教研室

[3] 复旦大学医学院眼耳鼻喉科医院电镜室

[4] 复旦大学医学院眼耳鼻喉科医院麻醉科上海市

[5] 上海市

来源：

中华麻醉学杂志 | 2001年 / 01期

关键词：

二异丙酚; 咪达唑仑; 硫喷妥; 脑缺血; 再灌注损伤;

D O I：

暂无

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

目的　观察异丙酚、咪唑安定和硫喷妥钠对鼠局灶脑缺血 /再灌注后的神经功能和病理结果的影响。方法　雄性SD大鼠 ,采用可逆性大脑中动脉内线栓法诱发局灶脑缺血。缺血 3h ,再灌注 2 4h后 ,作神经功能缺陷评估 ,然后取脑 ,TTC染色 ,用Image软件系统作图像分析 ,计算脑梗塞和脑水肿容积 ,电镜下观察梗塞边缘组织的细胞超微结构。动物分五组 :缺血组、再灌注组、用药组(异丙酚、咪唑安定和硫喷妥钠 )。结果　异丙酚和咪唑安定明显改善鼠神经功能缺陷程度 ,降低脑梗塞和脑水肿容积 ,并减少梗塞边缘组织细胞死亡。异丙酚的脑保护效应强于咪唑安定。结论　异丙酚和咪唑安定有拮抗鼠局灶脑缺血 /再灌注损伤的作用

引用

页码：50 / 52

页数：3

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