骨关节炎的软骨细胞凋亡机制

被引：40

作者：

袁芳 ^{[1
]}

何晓瑾 ^{[1
]}

邱亦江 ^{[2
]}

高祥 ^{[3
]}

机构：

[1] 南京中医药大学

[2] 南京市鼓楼区疾病预防控制中心

[3] 辽宁省凌源市中心医院

来源：

实用医学杂志 | 2015年 / 31卷 / 04期

关键词：

D O I：

暂无

中图分类号：

R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

<正>骨关节炎(osteoarthritis,OA)是一种退行性关节病,常见于老年人。目前ΟΑ的具体发病机制尚不明确,当骨关节软骨基质降解后,会导致骨钙质出现沉积现象;骨关节中凋亡的软骨细胞,未能全部清除,遗留在软骨中,对软骨细胞功能造成严重影响;在骨关节中的软骨细胞处于凋亡时期,若其基质合成较低,将导致ΟΑ的发生[1],故阐明软骨细胞凋亡的机制很有意义。本文将着重从信号通路、细胞因子、基因三方面对OA软骨细胞凋亡机制作一综述。

引用

页码：666 / 668

页数：3

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