肺癌耐药机制研究进展

被引:9
作者
李玉光
马利军
张罗献
机构
[1] 河南省人民医院呼吸科
关键词
肺癌; 耐药; 化学治疗;
D O I
暂无
中图分类号
R734.2 [肺肿瘤];
学科分类号
100117 [系统生物医学];
摘要
<正>肺癌是最常见的恶性肿瘤之一,75%的患者就诊时已是晚期,失去了手术治疗的机会。因此,化学治疗及分子靶向治疗成为肺癌的重要治疗手段,可以显著延长患者的生存期,减轻症状,提高生活质量。然而肿瘤细胞对药物的耐受
引用
收藏
相关论文
共 9 条
[1]
Akt1 inhibition by RNA interference sensitizes human non-small cell lung cancer cells to cisplatin [J].
Lee, Myoung Woo ;
Kim, Dae Seong ;
Min, Na Young ;
Kim, Heung Tae .
INTERNATIONAL JOURNAL OF CANCER, 2008, 122 (10) :2380-2384
[2]
PTEN expression in non–small-cell lung cancer: evaluating its relation to tumor characteristics; allelic loss; and epigenetic alteration.[J].Carmen J. Marsit;Shichun Zheng;Kenneth Aldape;Philip W. Hinds;Heather H. Nelson;John K. Wiencke;Karl T. Kelsey.Human Pathology.2005, 7
[3]
KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib [J].
Pao, W ;
Wang, TY ;
Riely, GJ ;
Miller, VA ;
Pan, QL ;
Ladanyi, M ;
Zakowski, MF ;
Heelan, RT ;
Kris, MG ;
Varmus, HE .
PLOS MEDICINE, 2005, 2 (01) :57-61
[4]
Molecular basis of cellular response to cisplatin chemotherapy in non-small cell lung cancer (Review) [J].
Wang, GD ;
Reed, E ;
Li, QQ .
ONCOLOGY REPORTS, 2004, 12 (05) :955-965
[5]
Identification of Fas (APO-1/CD95) and p53 gene mutations in non-small cell lung cancer [J].
Boldrini, L ;
Faviana, P ;
Gisfredi, S ;
Di Quirico, D ;
Lucchi, M ;
Mussi, A ;
Angeletti, CA ;
Baldinotti, F ;
Fogli, A ;
Simi, P ;
Basolo, F ;
Pingitore, F ;
Fontanini, G .
INTERNATIONAL JOURNAL OF ONCOLOGY, 2002, 20 (01) :155-159
[6]
In vitro and in vivo characterization of XR11576, a novel, orally active, dual inhibitor of topoisomerase I and II [J].
Mistry, P ;
Stewart, AJ ;
Dangerfield, W ;
Baker, M ;
Liddle, C ;
Bootle, D ;
Kofler, B ;
Laurie, D ;
Denny, WA ;
Baguley, B ;
Charlton, PA .
ANTI-CANCER DRUGS, 2002, 13 (01) :15-28
[7]
Differential modulation of chemosensitivity to alkylating agents and platinum compounds by DNA repair modulators in human lung cancer cell lines [J].
Heim, MM ;
Eberhardt, W ;
Seeber, S ;
Müller, MR .
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2000, 126 (04) :198-204
[8]
晚期非小细胞肺癌组织中ERCC-1、Metallothionein、p53表达与铂类耐药性及预后的相关性分析 [J].
黄培钰 ;
梁小曼 ;
林素瑕 ;
罗荣臻 ;
侯景辉 ;
张力 .
癌症, 2004, (07) :845-850
[9]
PTEN mutations are common in sporadic microsatellite stable colorectal cancer..Nassif NT; Lobo GP; Wu X; et al;.Oncogene.2004,