西地那非对慢性心衰大鼠左室功能的影响

被引：2

作者：

高辉德

邵东华

束微微

杭黎华

陈正

机构：

[1] 江苏大学附属人民医院麻醉科

来源：

南京医科大学学报(自然科学版) | 2013年 / 33卷 / 04期

关键词：

西地那非; 慢性心衰; 左室功能; 转化生长因子-β1; 羟脯氨酸;

D O I：

暂无

中图分类号：

R541.6 [血液循环衰竭];

学科分类号：

100201 [内科学];

摘要：

目的:探讨西地那非对慢性心衰大鼠左室功能及对血清中转化生长因子-β1(TGF-β1)和心肌组织中羟脯氨酸(Hyp)含量的影响。方法:雌性SD大鼠随机分为对照组、心衰组、西地那非治疗组,每组7只。对照组大鼠为正常大鼠;心衰组腹腔注射阿霉素制作心衰模型;西地那非治疗组为心衰造模成功后给予西地那非21 mg/(kg.d)灌胃,连续4周;心衰组与对照组大鼠给予安慰剂(1 ml蒸馏水)灌胃,连续4周。造模10周后心脏超声分别测定各组大鼠左室舒张末期内径(LVDd)、左室收缩末期内径(LVDs)、左室射血分数(EF)、左室短轴缩短率(FS);酶联免疫吸附试验(ELISA法)检测各组大鼠血清中TGF-β1的水平,Hyp试剂盒检测各组大鼠左室心肌组织中胶原蛋白的含量。结果:心衰组与对照组和西地那非治疗组比较,LVDs、LVDd及血清中TGFβ-1水平明显升高(P﹤0.01);EF、FS明显降低(P﹤0.01);心衰组大鼠左室心肌组织Hyp含量明显升高,与对照组相比,P﹤0.01,与治疗组相比,P﹤0.05。结论:西地那非可改善慢性心衰大鼠的左室舒缩功能,降低血清TGF-β1水平和减少心肌组织中胶原的沉积。

引用

页码：471 / 474

页数：4

共 8 条

[1]

New Insights into the Regulation of Epithelial–Mesenchymal Transition and Tissue Fibrosis.[J].KangAe Lee;Celeste M. Nelson.International Review of Cell and Molecular Biology.2012,

[2]

Sildenafil and B-Type Natriuretic Peptide Acutely Phosphorylate Titin and Improve Diastolic Distensibility In Vivo [J].

Bishu, Kalkidan ;

Hamdani, Nazha ;

Mohammed, Selma F. ;

Kruger, Martina ;

Ohtani, Tomohito ;

Ogut, Ozgur ;

Brozovich, Frank V. ;

Burnett, John C., Jr. ;

Linke, Wolfgang A. ;

Redfield, Margaret M. .

CIRCULATION, 2011, 124 (25) :2882-U299

[3]

Mechanisms of Cardiac Fibrosis in Inflammatory Heart Disease [J].

Kania, Gabriela ;

Blyszczuk, Przemyslaw ;

Eriksson, Urs .

TRENDS IN CARDIOVASCULAR MEDICINE, 2009, 19 (08) :247-252

[4]

Inhibition of TGF-β induced lung fibroblast to myofibroblast conversion by phosphodiesterase inhibiting drugs and activators of soluble guanylyl cyclase [J].

Dunkern, Torsten R. ;

Feurstein, Daniel ;

Rossi, Giovanni A. ;

Sabatini, Federica ;

Hatzelmann, Armin .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2007, 572 (01) :12-22

[5]

Change in the cells that express connective tissue growth factor in acute Coxsackievirus-induced myocardial fibrosis in mouse.[J].Soo-Hyeon Yun;Jae-Ok Shin;Byung-Kwan Lim;Kyoung-Li Kim;Chae-Ok Gil;Duk-Kyung Kim;Eun-Seok Jeon.Virus Research.2007, 1

[6]

Pharmacological preconditioning with sildenafil: Basic mechanisms and clinical implications.[J].Rakesh C. Kukreja;Fadi Salloum;Anindita Das;Ramzi Ockaili;Chang Yin;Yvonne A. Bremer;Patrick W. Fisher;Michael Wittkamp;John Hawkins;Eric Chou;Amit K. Kukreja;Xiaoyin Wang;Vijay R. Marwaha;Lei Xi.Vascular Pharmacology.2005, 5

[7]

Regional overexpression of insulin-like growth factor-I and transforming growth factor-β1 in the myocardium of patients with hypertrophic obstructive cardiomyopathy [J].