与细胞衰老相关的sirtuin家族

被引：6

作者：

朱建国

周杨

段新平

逄大欣

欧阳红生

机构：

[1] 吉林大学畜牧兽医学院,动物胚胎工程吉林省重点实验室

来源：

生命的化学 | 2010年 / 30卷 / 05期

关键词：

细胞衰老; sirtuins家族; p53; NF-κB; FoxO; PGC-1; mTOR;

D O I：

10.13488/j.smhx.2010.05.011

中图分类号：

Q343 [细胞遗传学];

学科分类号：

071007 [遗传学];

摘要：

衰老是发育过程中的普遍现象,是生理功能衰退过程中呈现的一系列特定变化,趋向于疾病发生的复杂过程。细胞衰老是由于端粒缩短、DNA损伤、氧化应激和原癌基因激活中特征分子的改变等产生的一种生理变化。本篇综述通过总结衰老信号通路中的年龄相关基因sirtuins家族与核因子(NF)-κB转录因子家族、p53、FoxO、PGC-1、mTOR等的相互作用,为我们研究衰老进程并在延缓衰老和自然死亡方面提供了可靠的依据。

引用

收藏

页码：744 / 750

页数：7

相关论文

共 15 条

[1]

SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells.[J].Marcia C. Haigis;Raul Mostoslavsky;Kevin M. Haigis;Kamau Fahie;Danos C. Christodoulou;Andrew J. Murphy;David M. Valenzuela;George D. Yancopoulos;Margaret Karow;Gil Blander;Cynthia Wolberger;Tomas A. Prolla;Richard Weindruch;Frederick W. Alt;Leonard Guarente.Cell.2006, 5

[2]

C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span [J].

Berdichevsky, Ala ;

Viswanathan, Mohan ;

Horvitz, H. Robert ;

Guarente, Leonard .

CELL, 2006, 125 (06) :1165-1177

[3]

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6 [J].

Mostoslavsky, R ;

Chua, KF ;

Lombard, DB ;

Pang, WW ;

Fischer, MR ;

Gellon, L ;

Liu, PF ;

Mostoslavsky, G ;

Franco, S ;

Murphy, MM ;

Mills, KD ;

Patel, P ;

Hsu, JT ;

Hong, AL ;

Ford, E ;

Cheng, HL ;

Kennedy, C ;

Nunez, N ;

Bronson, R ;

Frendewey, D ;

Auerbach, W ;

Valenzuela, D ;

Karow, M ;

Hottiger, MO ;

Hursting, S ;

Barrett, JC ;

Guarente, L ;

Mulligan, R ;

Demple, B ;

Yancopoulos, GD ;

Alt, FW .

CELL, 2006, 124 (02) :315-329

[4]

Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic β cells [J].

Bordone, L ;

Motta, MC ;

Picard, F ;

Robinson, A ;

Jhala, US ;

Apfeld, J ;

McDonagh, T ;

Lemieux, M ;

McBurney, M ;

Szilvasi, A ;

Easlon, EJ ;

Lin, SJ ;

Guarente, L .

PLOS BIOLOGY, 2006, 4 (02) :210-220

[5]

FoxO1 protects against pancreatic β cell failure through NeuroD and MafA induction [J].

Kitamura, YI ;

Kitamura, T ;

Kruse, JP ;

Raum, JC ;

Stein, R ;

Gu, W ;

Accili, D .

CELL METABOLISM, 2005, 2 (03) :153-163

[6]

Increased dosage of mammalian Sir2 in pancreatic β cells enhances glucose-stimulated insulin secretion in mice [J].

Moynihan, KA ;

Grimm, AA ;

Plueger, MM ;

Bernal-Mizrachi, E ;

Ford, E ;

Cras-Méneur, C ;

Permutt, MA ;

Imai, SI .

CELL METABOLISM, 2005, 2 (02) :105-117

[7]

FoxOs at the crossroads of cellular metabolism, differentiation, and transformation [J].

Accili, D ;

Arden, KC .

CELL, 2004, 117 (04) :421-426

[8]

The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase [J].

North, BJ ;

Marshall, BL ;

Borra, MT ;

Denu, JM ;

Verdin, E .

MOLECULAR CELL, 2003, 11 (02) :437-444

[9]

Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly [J].

Rose, G ;

Dato, S ;

Altomare, K ;

Bellizzi, D ;

Garasto, S ;

Greco, V ;

Passarino, G ;

Feraco, E ;

Mari, V ;

Barbi, C ;

BonaFe, M ;

Franceschi, C ;

Tan, Q ;

Boiko, S ;

Yashin, AI ;

De Benedictis, G .

EXPERIMENTAL GERONTOLOGY, 2003, 38 (10) :1065-1070

[10]

The phosphorylation status of nuclear NF-κB determines its association with CBP/p300 or HDAC-1 [J].

Zhong, HH ;

May, MJ ;

Jimi, E ;

Ghosh, S .

MOLECULAR CELL, 2002, 9 (03) :625-636