脂联素与血管内皮细胞功能障碍的相关性

被引：19

作者：

孙慧

吴永全

严松彪

机构：

[1] 北京友谊医院心脏中心心血管内科

来源：

中国动脉硬化杂志 | 2011年 / 19卷 / 11期

关键词：

脂联素; 内皮功能障碍; 动脉粥样硬化;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

100104 ;

摘要：

代谢综合征的组成成份致冠状动脉粥样硬化性心脏病发生发展的内在机制尚待进一步研究。脂联素作为一种脂肪细胞因子,与内皮依赖性血管舒张功能呈独立正相关,并且是后者的独立决定因素;通过多重信号传导途径上调内皮细胞一氧化氮合成酶活性、增加一氧化氮生成,抑制内皮细胞氧化应激反应、降低细胞损伤程度,阻断内皮细胞炎症信号传导、减轻血管炎症反应。因此,脂联素可能是联系代谢综合征与心血管疾病的枢纽,可以考虑利用脂联素改善代谢综合征患者的血管内皮功能,进而预防或延缓心血管疾病的发生发展。

引用

页码：952 / 956

页数：5

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