肿瘤血管标志物CD105的研究及应用进展

被引：5

作者：

张英辉 ^{[1
]}

陈素琴 ^{[2
]}

机构：

[1] 石家庄市第四医院产科

[2] 河北医科大学附属第二医院妇科

来源：

医学综述 | 2009年 / 15卷 / 01期

关键词：

CD105; 肿瘤; 诊断; 预后; 治疗;

D O I：

暂无

中图分类号：

R730.4 [肿瘤诊断学];

学科分类号：

100214 [肿瘤学];

摘要：

CD105是一个特异表达于新生血管内皮的糖蛋白,主要标记具有增殖活性的内皮细胞。肿瘤生长和浸润有赖于血管生成,新生的血管提供给肿瘤组织营养及氧分,为肿瘤组织增殖提供了基础。CD105是肿瘤新生血管的标志物,其标记的微血管密度,优于其他标志物,更能反映肿瘤的增殖状态和预后,血管生成是肿瘤生长和转移的推动力,以CD105为靶向,抑制肿瘤血管生长的治疗肿瘤的方法成为目前研究的热点。

引用

页码：68 / 70

页数：3

共 8 条

[1]

Endoglin (CD105) as a prognostic factor in head and neck squamous cell carcinoma [J].

Kyzas, Panayiotis A. ;

Agnantis, Niki J. ;

Stefanou, Dimitrios .

VIRCHOWS ARCHIV, 2006, 448 (06) :768-775

[2]

Prognostic significance of angiogenesis evaluated by CD105 expression compared to CD31 in 905 breast carcinomas: Correlation with long-term patient outcome [J].

Dales, JP ;

Garcia, S ;

Andrac, L ;

Carpentier, S ;

Ramuz, O ;

Lavaut, MN ;

Allasia, C ;

Bonnier, P ;

Charpin, C .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2004, 24 (05) :1197-1204

[3]

Endoglin (CD105) expression in endometrial carcinoma [J].

Saad, RS ;

Jasnosz, KM ;

Tung, MY ;

Silverman, JF .

INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 2003, 22 (03) :248-253

[4]

Correlation between apoptotic index and angiogenesis in non-small cell lung cancer: comparison between CD105 and CD34 as a marker of angiogenesis [J].

Tanaka, F ;

Otake, Y ;

Yanagihara, K ;

Kawano, Y ;

Miyahara, R ;

Li, M ;

Ishikawa, S ;

Wada, H .

LUNG CANCER, 2003, 39 (03) :289-296

[5]

Imaging of tumour neovasculature by targeting the TGF-β binding receptor endoglin [J].

Bredow, S ;

Lewin, M ;

Hofmann, B ;

Marecos, E ;

Weissleder, R .

EUROPEAN JOURNAL OF CANCER, 2000, 36 (05) :675-681

[6]

Perfusion of99Tcm-labeled CD105Mab into kidneys from patients with renal carcinoma suggests that CD105is a promising vascular target..Costello B;Li C;Duff S;et al;.Int J Cancer.2004,

[7]

Prognostic impact of VEGF; CD31; CD34; and CD105 expression and tumour vessel invasion after radical surgery for IB-IIA non-small cell lung cancer..Mineo TC;Ambrogi V;Baldi A;Rabitti C;Bollero P;Vincenzi B;Tonini G;.J Clin Pathol.2004, 06

[8]

Tumor neoangiogenesis by CD31 and CD105 expression evaluation in breast carcinoma tissue microarrays..Charpin C; Dales JP; Garcia S; et al;.Clin Cancer Res.2004,

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