TFPI-2基因与消化道肿瘤关系的研究进展

被引：4

作者：

孙振阳

汤志刚

机构：

[1] 安徽医科大学附属安徽省立医院普通外科

来源：

中华肿瘤防治杂志 | 2008年 / 03期

基金：

安徽省自然科学基金;

关键词：

腹部肿瘤; 糖蛋白类; 综述文献;

D O I：

10.16073/j.cnki.cjcpt.2008.03.004

中图分类号：

R735 [消化系肿瘤];

学科分类号：

100112 [医学生物化学与分子生物学];

摘要：

组织因子途径抑制物2(tissue factor path-way inhibitor2,TFPI-2)是一种广谱的丝氨酸蛋白酶抑制物,可抑制包括纤溶酶、胰蛋白酶、基质金属蛋白酶(matrix metalloproteinases,MMPs)在内的多种蛋白酶,而MMPs参与了细胞外基质的重塑,在肿瘤细胞的浸润和转移、伤口愈合、血管新生、纤维蛋白溶解及动脉粥样硬化等生理和病理过程中发挥重要作用。TFPI-2可通过维持细胞外基质的完整、调节肿瘤血管生成、调控肿瘤细胞细胞凋亡及血液凝固等机制调节胰腺癌、食管癌及胃癌等消化道肿瘤细胞的侵袭转移。越来越多的研究表明,TFPI-2能明显抑制肿瘤中MMPs的活性与功能等从而抑制肿瘤的侵袭与转移,并成为肿瘤基因治疗的新靶点。

引用

收藏

页码：227 / 230

页数：4

相关论文

共 6 条

[1]

胃管状腺癌组织中Fos和Jun蛋白表达及临床意义 [J].

侯仁好 ;

初晓艺 ;

刘希双 .

中华肿瘤防治杂志, 2006, (24) :1860-1862

[2]

Restoration of tissue factor pathway inhibitor inhibits invasion and tumor growth in vitro and in vivo in a malignant meningioma cell line [J].

Kondraganti, Shakuntala ;

Gondi, Christopher S. ;

Gujrati, Meena ;

McCutcheon, Ian ;

Dinh, Dzung H. ;

Rao, Jasti S. ;

Olivero, William C. .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2006, 29 (01) :25-32

[3]

Genetic variations in the human TFPI-2 gene and its promoter region by denaturing high performance liquid chromatography [J].

Siegling, S ;

Thyzel, E ;

Brinkmann, T ;

Prohaska, W ;

Götting, C ;

Kleesiek, K .

THROMBOSIS RESEARCH, 2004, 113 (05) :341-343

[4]

Computer model of the interaction of human TFPI-2 Kunitz-type serine protease inhibitor with human plasmin [J].

Hubé, F ;

Reverdiau, P ;

Iochmann, S ;

Gruel, Y .

THROMBOSIS RESEARCH, 2003, 111 (03) :197-198

[5]

Matrix localization of tissue factor pathway inhibitor-2/matrix-associated serine protease inhibitor (TFPI-2/MSPI) involves arginine-mediated ionic interactions with heparin and dermatan sulfate: Heparin accelerates the activity of TFPI-2/MSPI toward plasmin [J].

Liu, YY ;

Stack, SM ;

Lakka, SS ;

Khan, AJ ;

Woodley, DT ;

Rao, JS ;

Rao, CN .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1999, 370 (01) :112-118

[6]

Extracellular matrix-associated serine protease inhibitors (M(r) 33,000, 31,000, and 27,000) are single-gene products with differential glycosylation: cDNA cloning of the 33-kDa inhibitor reveals its identity to tissue factor pathway inhibitor-2 [J].

Rao, CN ;

Reddy, P ;

Liu, YY ;

OToole, E ;

Reeder, D ;

Foster, DC ;

Kisiel, W ;

Woodley, DT .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1996, 335 (01) :82-92