左侧乳腺癌改良根治术后切线野放疗中心脏最大距离预测心脏剂量探讨

被引:3
作者
王升晔
杜向慧
白雪
苏锋
王跃珍
陈建祥
史国栋
郑远达
王谨
陈明
机构
[1] 杭州,浙江省肿瘤医院放疗科
关键词
心脏最大距离; 心脏平均剂量; 乳腺肿瘤/放射疗法;
D O I
暂无
中图分类号
R737.9 [乳腺肿瘤]; R730.55 [放射疗法];
学科分类号
100214 [肿瘤学]; 100234 [放射肿瘤学];
摘要
目的探讨用切线野心脏最大距离(MHD)来预测左侧乳腺癌心脏照射剂量的可行性。方法以2010—2011年在我院行辅助性左胸壁切线野放疗的40例左侧乳腺癌改良根治术后患者为研究对象, 对每位受试对象用3D TPS计算MHD, 全心脏、冠状动脉左前降支、左心室及心前区Dmean以及对侧乳腺组织厚度和胸骨至体表厚度。用曲线拟合方法分析MHD与上述各Dmean相关性, R2>0.8为可靠性非常好。结果 40例患者中MHD在1.14~5.34 cm之间[(2.67±0.98)cm]。MHD与全心脏Dmean的拟合一次、二次和三次方程的R2值分别为0.869、0.875和0.883(3个P=0.000), 与心前区Dmean的分别为0.777、0.799和0.813(3个P=0.000), 与左心室Dmean的分别为0.598、0.601和0.633(3个P=0.000), 与冠状动脉左前降支Dmean的分别为0.418、0.470和0.472(3个P=0.000)。心脏各Dmean不受身体脂肪厚度影响。结论该模型提示MHD是预测左侧乳腺癌切线野放疗中全心脏、心前区Dmean的可靠指标。
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